Oh Randy, I am so THRILLED to hear of your positive response to the 
medications, and that your vet was so helpful. (What does your vet think of the 
response?) You may think that 15% haematocrit is still very sick, and it is 
still well outside the normal range, but you’ve basically had a 60% increase in 
haematocrit in 3 weeks. That is quite amazing and wonderful. It is as good a 
result as you would have had with 2 units of blood being given as a 
transfusion, only it is much better than a transfusion because Curly is 
producing her own cells, rather than temporarily filling up with someone else’s 
blood.

With respect to the Doxy, I am not sure. If it were me, I would probably want 
to continue if you can. You’ve had a very good result. Why mess with the 
formula? I can’t say definitively, one way or the other, since I very much 
figured things out by running weekly blood work and if I saw a dip or a 
reversal in the numbers, I would adjust the medication accordingly. I don’t 
know if I am right about my Doxy theory (and it is just pure conjecture on my 
part, based on my non-vet research) but I really think that the Doxy is part of 
the effective package. I feel that the Doxy holds the virus in check – perhaps 
slowing down its reproduction by inhibiting RNA synthesis – enough to allow the 
body to make some progress with the Winstrol. I don’t think that the Winstrol 
on its own is enough.

With the Doxy, I used to scrape the quarter tablet into a slab of butter to 
coat it with butter, to help it slide down better, since the quarter table it 
very dry and scratchy. I also posted recently that the Doxy we get from vets 
(and even from our doctors) is the same as what you can get to treat fish or 
birds, in a pet store, and that is sold in powdered packages of 100 mg (same as 
1 tablet). A prescription isn’t needed for it, and because it is powdered, it 
can be mixed into food or liquid.

Great news, too, with your success in getting her to eat more and put on weight.

I love to hear good news on this front. Let’s hope she continues in the right 
direction.

Amani

From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of Randy 
Henke
Sent: January-19-17 9:53 PM
To: felvtalk@felineleukemia.org
Subject: [Felvtalk] Curly's gradual improvement

It has been a little over a month ago that I asked for advice on this forum for 
our little girl, Curly.
At that point, I had little hope. She was so lethargic and her hematocrit had 
dipped to a critical 9%. I took everyone's advice, especially Amani's, and 
asked our vet for Predisolone, Winstrol and Doxycycline.
According to her latest CBC two weeks ago, she is still a very sick kitty but 
her hematocrit rebounded to 15% which I know is still very low. All other 
numbers are improving slowly as well. That was after less than three weeks of 
treatment.
She is due for another CBC next Tuesday and I am hopeful we will see more 
improvement. I've noticed her gums are more pink which I believe is a good sign.
We were still having problems with getting her to eat. She would have her good 
days and her bad days but her weight was still creeping down. Last week I asked 
our vet about Mirtazapine and our vet agreed to give us a prescription for it. 
I have to thank Robert for mentioning this in one of his posts.

One day last week she didn't want to eat so I gave her a quarter pill (3.75 mg) 
which is the dose our vet prescribed to give her daily. The result was 
phenomenal and almost a little scary. She was bouncing off the walls within a 
few hours and eating everything she could get her paws on. I almost felt a 
little sorry for her because it was like she couldn't sit still for more than a 
couple of minutes. But it was like getting our old Curly back again in just a 
single day!
The effect tapered off after a couple of days and we didn't feel comfortable 
giving her another dose until she stopped eating again because of how dramatic 
the change was. I've read online that a smaller dose could be effective if 
given every 72 hours so we are going to try doing that so she keeps eating. It 
was incredible to see her weight go up by a quarter pound in just a couple of 
days.
We are continuing the Prednisolone and Winstrol at the recommended doses but 
our two week Doxycycline prescription ran out over a week ago. She does appear 
to still be making improvement without it but I'm wondering if I should ask for 
another prescription to keep that going as well.
I always worry about giving her the quarter pill of Doxy because I know it can 
cause esophageal damage if it isn't followed by liquids. I was following the 
pill with the liquid Winstrol solution but wasn't sure if that was enough.
Many thanks to everyone who gave us advice. It looks like we might have our 
Curly back for at least a while yet and it's all because of you people.
Randy

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