I am unable to attach the literature regarding the ability of Doxycycline to
interfere with RNA replication and/or interfere with viral infection, but here
are a few titles to look up on the Internet:
- Antiviral activity of doxycycline against vesicular stomatitis virus in vitro
- FEMS Microbiol Lett. 2015
- Control of small inhibitory RNA levels and RNA interference by doxycycline
induced activation of a minimal RNA polymerase III promoter - 2006 Nucleic
Acids Res. 34
- Inhibitory effect of doxycycline against dengue virus replication in vitro -
October 2013 Archives of Virology 159(4)
- Study of the antiviral activity of some derivatives of tetracycline and
non-steroid anti-inflammatory drugs towards dengue virus - August 2013 Tropical
Biomedicine 30(4):1-10 (BY THE WAY - DOXYCYCLINE IS A TETRACYCLINE)
- A study of the clinical activity of a gel combining monocaprin and
doxycycline: a novel treatment for herpes labialis. (2012) J Oral Path Med
The following paper was interesting in that it explored the role of Doxycycline
in inhibiting tumour cell proliferation, angiogenesis, metastasis and migration
of cancerous cells (including leukemic cells) from the bone marrow:
- Doxycycline inhibits leukemic cell migration via inhibition of matrix
metalloproteinases and phosphorylation of focal adhesion kinase - published
Molecular Medicine Reports, September 2015 Vol. 12, Issue 3.
P.S. - By the way, Bob. The other thing that was featured in that show last
night about the fight against Ebola, is that the same doctor who contracted it
and was declared symptom-free, later began to develop eye problems and when
they examined his eye, they found millions of the Ebola viruses in the eye. The
programme explained that the eye was an area of reduced immunity in the body,
and thus, the virus had found a breeding ground where it remained, though it
had been cleared from the rest of the body. They therefore began treating the
doctor's eye, and the treatment was ultimately successful. It brought to mind
the problems Yogi had had with his eyes, and I wondered if the answer was
similar - that the virus had had a toe-hold there.
From: Felvtalk [mailto:felvtalk-boun...@felineleukemia.org] On Behalf Of ROBERT
Sent: March-01-17 5:02 PM
Subject: Re: [Felvtalk] Knowing the " whys" of Win/Pred/Doxy
If we consider the extended time frame for Doxy and multiple courses of other
ABX it makes a certain "intuitive" sense that a non bacterial infection is
going to require a longer period of time to have whatever non-specific (
read... not related to bacterial infection necessarily)... So little research
money appears to be devoted to FeLV that I don't know that we'll know in the
next decade unless the continuing demands of consumers ( who do NOT want to
hear , in this day and age of " Miracles") that there is _ no hope_ for their
pets) alter this course. I STILL bristle when I think of the closed minds in
the medical and Veterinary community and SO resent that businessmen( Yes...that
is what the vast majority are turning into now that practices are being forced
to consolidate into " Health Systems")..
hold the power of life and death over us AND our pets. On the plus side....
with the business model being what it is ( and in contrast to the lost art of "
professionalism") The CONSUMER is always right. Vets will be forced, in the
future, to work more closely with the "
customers" wishes as attachment to a given vet will become less common as time
goes on and people will " practice shop " for the answers they want until such
time as Vet services become so expensive that insurance becomes a " must have "
and ultimately go the way of medicine ( ie...being confined to a slate of
again....limiting choice)... But... there are some years to go before that
happens and I feel that there IS a window of opportunity happening NOW and for
the next few years for people to have some real influence on how Vets
practice.... I am betting, for example, that had I had the money to go to a
more " well to do " neighborhood where people are more demanding and better
informed I could have found a vet to cooperate... Here in the "sticks" people
just blindly accept what the vet has to say and they still enjoy the freedom of
calling all the shots..... This WILL end over the next couple of years. I
learned a lot with this first experience and made mistakes that I WILL NOT make
BTW.... Do you have any literature in support of the AntiRNA effects of
Doxy... I am SO happy that there are still a couple of things out there
that we still can get our hands on that don't have to pass muster with script
pad businessmen.... STILL I am also not advocating the the medically ill
prepared take it upon themselves to decide that THEY will decide what is best
for their animal... If we are going to go above and beyond our Vets advice it
would best be with very sound reasoning and an EXCELLENT understanding of what
we are doing and why. Anything less and the community of Veterinary
practitioners could easily dismiss our successes as "dumb luck" or ascribe them
to " unknown" factors..... I think this is particularly important re:
Winstrol/Pred/Doxy I'd hate to see people going to their vets asking for this
combination of drugs and really having an inadequate understanding of why they
are asking for beyond the fact that it's been recommended on our forum...
For myself... I am clear on the Whys of Winstrol and Doxy ( though will be
looking for more lit support on the RNA effects of Doxy) but not clear on the
whys of the Pred.
Sorry for taking up so much space here but I'm having an " attack " of missing
my little guy and am tremulous about being caught in the same position if I
take in another FeLV as I am inclined to do....
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