Then probably best to do so. Figaro will read off of you, and only make the situation worse. It's tough to deal with this kind of issue, and if it frustrates you to this extent, it is probably best to let someone else try. Have you had Figaro retested? Turning an outside cat into an inside cat is a long-term project, and as an intact male, he's still marking (and yes, you) and that's not likely to change. But placing a + cat is difficult in most places. You could look up "Feline leukemia sanctuary", and maybe there's someone near you. Is there a reason he has not been neutered? Have you had your other cats vaccinated against FeLV? Is Figaro showing any symptoms? What has his age been guessed to be?

Hope you find a good solution,

Margo

-----Original Message-----
From: Jennifer Olson
Sent: Mar 2, 2017 8:38 AM
To: felvtalk@felineleukemia.org
Subject: [Felvtalk] Losing patience

Figaro is adorable, but I'm so frustrated with the whole situation-
I'm begining to consider other livining arrangements... aka placement...

On Mar 2, 2017 3:19 AM, "ROBERT CHAPEL" <bcha...@optonline.net> wrote:
Thanks Amani... this is very helpful and I will do my best to locate these references... preferably the full articles if they don't charge too much for them ( I no longer work in hospitals and don't have access to full medical databases ( for free)...

VERY interesting about the ebola virus and the eyes.... it does indeed appear that the virus established a foothold in Yogi's eyes....   BUT... it was also via the eyes that I was able to introduce antiviral meds that my Veterinary opthalmologist was using off label.....  Of course the target for these meds was the Herpes Virus....but it too ,is,  a retro Virus and these meds "might" have had some effect on the FeLV virus as well
had I used them for a longer time ( though I would have had to have sold my house to do so : )
You can find ALL sorts of aid for these Anti Virals if you are using them for HIV or Herpes 1 or 2 but they are hard to locate at discount for Veterinary Use.....  I really am VERY concerned at the price of Vet services as I feel they will ultimately reduce the number of pet owners.....  I was able to easily afford to keep 4 cats on a rather low Social Worker income back in the 80's but keeping one ill FeLV in 2017 can easily add 400.00 a month to ones expenses....  Many people who might formerly have adopted multiple cats will now only take in one or  two.....  All the more reason for forums like ours as it is up to us to share our knowledge and experiences to help each other avoid total reliance on a veterinary system that is not always working to preserve our FeLV cats lives.....    


Hi Bob

I am unable to attach the literature regarding the ability of Doxycycline to interfere with RNA replication and/or interfere with viral infection, but here are a few titles to look up on the Internet:

- Antiviral activity of doxycycline against vesicular stomatitis virus in vitro - FEMS Microbiol Lett. 2015

- Control of small inhibitory RNA levels and RNA interference by doxycycline induced activation of a minimal RNA polymerase III promoter - 2006 Nucleic Acids Res. 34

- Inhibitory effect of doxycycline against dengue virus replication in vitro - October 2013 Archives of Virology 159(4)
- Study of the antiviral activity of some derivatives of tetracycline and non-steroid anti-inflammatory drugs towards dengue virus - August 2013 Tropical Biomedicine 30(4):1-10   (BY THE WAY - DOXYCYCLINE IS A TETRACYCLINE)

- A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialis. (2012) J Oral Path Med 41:61-67



The following paper was interesting in that it explored the role of Doxycycline in inhibiting tumour cell proliferation, angiogenesis, metastasis and migration of cancerous cells (including leukemic cells) from the bone marrow:

- Doxycycline inhibits leukemic cell migration via inhibition of matrix metalloproteinases and phosphorylation of focal adhesion kinase - published Molecular Medicine Reports, September 2015 Vol. 12, Issue 3.


Amani

P.S. - By the way, Bob. The other thing that was featured in that show last night about the fight against Ebola, is that the same doctor who contracted it and was declared symptom-free, later began to develop eye problems and when they examined his eye, they found millions of the Ebola viruses in the eye. The programme explained that the eye was an area of reduced immunity in the body, and thus, the virus had found a breeding ground where it remained, though it had been cleared from the rest of the body. They therefore began treating the doctor's eye, and the treatment was ultimately successful. It brought to mind the problems Yogi had had with his eyes, and I wondered if the answer was similar - that the virus had had a toe-hold there.


-----Original Message-----
From: Felvtalk [mailto:felvtalk-bounces@felineleukemia.org] On Behalf Of ROBERT CHAPEL
Sent: March-01-17 5:02 PM
To: felvtalk@felineleukemia.org
Cc: felvtalk@felineleukemia.org
Subject: Re: [Felvtalk] Knowing the " whys" of Win/Pred/Doxy

Amani...

If we consider the extended time frame for Doxy and multiple courses of other ABX it makes a certain "intuitive" sense that a non bacterial infection is going to require a longer period of time to have whatever non-specific ( read... not related to bacterial infection necessarily)...? So little research money appears to be devoted to FeLV that I don't know that we'll know in the next decade unless the continuing demands of consumers ( who do NOT want to hear , in this day and age of " Miracles") that there is _ no hope_ for their much loved
pets) alter this course.??? I STILL bristle when I think of the closed minds in the medical and Veterinary community and SO resent that businessmen( Yes...that is what the vast majority are turning into now that practices are being forced to consolidate into " Health Systems").. hold the power of life and death over us AND our pets.?? On the plus side.... with the business model being what it is ( and in contrast to the lost art of " professionalism")? The CONSUMER is always right.? Vets will be forced, in the future, to work more closely with the " customers" wishes as attachment to a given vet will become less common as time goes on and people will " practice shop " for the answers they want until such time as Vet services become so expensive that insurance becomes a " must have " and ultimately go the way of medicine ( ie...being confined to a slate of approved practitioners... again....limiting choice)...? But... there are some years to go before that happens and I feel that there IS a window of opportunity happening NOW and for the next few? years for people to have some real influence on how Vets practice....?? I am betting, for example, that had I had the money to go to a more " well to do " neighborhood where people are more demanding and better informed I could have found a vet to cooperate... Here in the "sticks" people just blindly accept what the vet has to say and they still enjoy the freedom of calling all the shots.....?? This WILL end over the next couple of years.? I learned a lot with this first experience and made mistakes that I WILL NOT make again.

BTW....? Do you have any literature in support of the AntiRNA effects of Doxy...???? I am SO happy that there are still a couple of things out there that we still can get our hands on that don't have to pass muster with script pad businessmen....? STILL I am also not advocating the the medically ill prepared take it upon themselves to decide that THEY will decide what is best for their animal... If we are going to go above and beyond our Vets advice it would best be with very sound reasoning and an EXCELLENT understanding of what we are doing and why.?? Anything less and the community of Veterinary practitioners could easily dismiss our successes as "dumb luck" or ascribe them to " unknown" factors.....? I think this is particularly important re: Winstrol/Pred/Doxy?? I'd hate to see people going to their vets asking for this combination of drugs and really having an inadequate understanding of why they are asking for beyond the fact that it's been recommended on our forum...??? For m
 yself... I am clear on the Whys of Winstrol and Doxy ( though will be looking for more lit support on the RNA effects of Doxy) but not clear on the whys of the Pred.
Sorry for taking up so much space here but I'm having an " attack " of missing my little guy and am tremulous about being caught in the same position if I take in another FeLV as I am inclined to do....



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