Dear NM-Users, We are trying to model with NONMEM 7.3 (FOCE.I) a dataset containing one measurement per minute for 68 individuals, for a total of 1440 measurements per individual. The dataset is therefore composed of ~100,000 rows. After having defined $SIZES adequately (LIM6 statement), the (successful) minimization of the algorithm takes few minutes, without any warning or error messages.
The problem is that the TABLE output step is nearly impossible to obtain. Even with the FIRSTONLY statement, no table can be obtained in a reasonable time period. Trying to limit the table contents to ID & IPRED only does not solve the issue. We performed some additional tests with MSF files as input. When applying MSF to a dataset composed of only ONE individual at a time, the table takes 24 hours to be generated. This would therefore take 68 days (if time increases proportionally... ?) to obtain PRED & IPRED for all individuals. When implementing the model in an alternative commercial software, the table is output in less than 20 minutes. A solution would be to use MSF on a reduced dataset i.e., with a (randomly) decreased number of measurements per individual, but we want to avoid this. What other solution do we have ? Can anyone provide some input on it ? Thanks ! Jean-Marie Martinez Modeling & Simulation Group Sanofi Montpellier
