Hi,
I'm not sure what data you're analysing and what your dosage schedules and sampling are but if ADDL is the same for each patient you could create a new variable (TVPC) and simply deduct that additional dosing history from your cumulative time from when you restarted the system (EVID=3 or 4). You code it simply as: TVPC=TIME- sum of all ADDLs So if you have 3 additional doses, each at a 24h interval it would look like: TVPC=TIME-72 Then you can plot your VPC with TVPC as idv. Regards, Andrzej Andrzej Bienczak MSc, MPharm, DiplPharm Pharmacometrics Group Division of Clinical Pharmacology Department of Medicine University of Cape Town K45 Old Main Building Groote Schuur Hospital Observatory, Cape Town 7925 South Africa phone: +27 21 650 4861 mobile: +27 839 842 675 email: andrzej.bienc...@gmail.com <mailto:andrzej.bienc...@gmail.com> From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of de Almeida, Camila Sent: 20 December 2016 01:46 PM To: nmusers@globomaxnm.com Subject: [NMusers] Generating TAD with ADDL dosing format Hello, I was wondering if I could get some guidance from this great group. My issue is primarily with some diagnostic analysis, but this is taking me back to an old NONMEM problem. My aim is to run a VPC on a model I implemented, and if possible change the idv to TAD instead of TIME. The reason for that is the VPC graph based on TIME looks dreadful as the data is sparse and from different studies of different lengths. I'm having issues generating the TAD output column from my NONMEM run. I naively assumed I could easily do that, but looking at the NONMEM archives it seems this gets tricky when your dosing events are written using ADDL. Has anyone ever managed to find a solution for this? And if not, is there an alternative way to run the VCP on TAD, do we really need to get this column from NONMEM's output? Thanks all, Camila de Almeida, PhD PKPD Scientist, Modelling & Simulation, IMED Oncology DMPK ____________________________________________________________________________ ____ AstraZeneca UK Limited R&D, Innovative Medicines P Please consider the environment before printing this e-mail _____ AstraZeneca UK Limited is a company incorporated in England and Wales with registered number:03674842 and its registered office at 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA. This e-mail and its attachments are intended for the above named recipient only and may contain confidential and privileged information. If they have come to you in error, you must not copy or show them to anyone; instead, please reply to this e-mail, highlighting the error to the sender and then immediately delete the message. For information about how AstraZeneca UK Limited and its affiliates may process information, personal data and monitor communications, please see our privacy notice at www.astrazeneca.com <https://www.astrazeneca.com>
