I think it would help if you provide the code and the reference and the
sample data set: some published papers contain typos, so it is hard to
give a general advice based on limited information
Thanks
Leonid
On 1/5/2017 10:44 AM, Zhu, Penny wrote:
Dear Ankekatrin, Jeroen and Sam
Many thanks for your kind suggestions.
I tried ADVAN9, ADVAN13 with different TOL numbers. They both returned
errors as well.
For ADVAN13
ERROR IN LSODI1: CODE 205
ERROR IN LSODI1: CODE 205
For ADVAN9
ERROR IN LSODA -1
ERROR IN LSODA -5
I also tried adding more simulation timepoints. I don’t think it made a
difference.
Does anybody have other suggestion? Should I try Monolix given that
NONMEM has numerical difficulties
Thank you very much and best regards!
* *
*Penny (Peijuan) Zhu, Ph.D.*
Associate Director Clinical Pharmacology
Cell: 862-926-9079
PD Bio-Pharma CDMA
Sandoz
1N025, 100 College Road West
Princeton, NJ 08540
*From:*ankekatrin.v...@uni-saarland.de
[mailto:ankekatrin.v...@uni-saarland.de]
*Sent:* Wednesday, January 04, 2017 3:33 PM
*To:* Zhu, Penny <penny....@sandoz.com>
*Subject:* Re: [NMusers] A problem with numerical integration
difficulties for a complex model
Hey Penny,
From my little experience with the TMDD modeling ADVAN 13 or 9 works
better.
Good luck
Katrin
Von: Sam Liao
Gesendet: Mittwoch, 4. Januar 21:28
Betreff: Re: [NMusers] A problem with numerical integration difficulties
for a complex model
An: Zhu, Penny, nmusers@globomaxnm.com <mailto:nmusers@globomaxnm.com>
Hi Penny,
You could try other ODE solver, such as ADVAN13 to see if you can get
around this problem.
But, If the data are too sparse, the time gap between two data points
might be too long to solve the ODE, you may want to consider adding some
dummy data points with EVID=2. Good luck with your TMDD modeling.
Best regards,
Sam Liao, PhD.
Pharmax Research
On 1/4/2017 8:53 AM, Zhu, Penny wrote:
Dear all
Sorry to bother you.
I have encountered a problem with a complex model, involve a full TMDD
PK model lined to a complicated multi-compartment PD model. I was only
doing a simulation based on a published paper so I would prefer not to
alter or simplify the model.
The model kept having numerical difficulties no matter how I modify the
TOL value (I have changed it from 0 to 6). And I am using ADVAN 8.
Does someone have any idea what else I should try to do to resolve it?
Here is the error message. The nonmem code and data are quite long and
I could send you the code/data as files if requested. Many many thanks
in advance for your kind help.
NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.
NO. OF REQUIRED SIGNIFICANT DIGITS IN SOLUTION VECTOR
TO DIFFERENTIAL EQUATIONS, 6, MAY BE TOO LARGE.
MESSAGE ISSUED FROM SIMULATION STEP
Best
Thank you very much and best regards!
*Penny (Peijuan) Zhu, Ph.D.*
PD Bio-Pharma CDMA
Sandoz
1N025, 100 College Road West
Princeton, NJ 08540
-- Sam Liao Pharmax Research Inc. 14 Upland, Irvine, CA 92602 Phone:
201-9882043 efax: 720-2946783 www.pharmaxresearch.com
<http://www.pharmaxresearch.com>
