Dear NMusers,
Genentech is hiring at all experience levels (multiple opportunities available) in South San Francisco, California *Welcome to join our great team and be part of amazing science to help patients.* Please apply through the links below. *Kind regards Angelica Quartino, Dan Lu and Jin Jin* --------------------------------------------------------------------------------- Angelica Quartino, Ph.D. *Modeling and Simulation (M&S) Group Leader OMNI* *Sr. Scientist, Clinical Pharmacology, gRED* *Genentech Inc* *Address: Mail Stop 463A, **1 DNA Way, S**outh San **Francisco**, CA 94080* *Office: 650- <650-467-2198>467-6662 Mobile: 415-528-0744 Email: quartino.angel...@gene.com <quartino.angel...@gene.com>* *MODELING AND SIMULATION THERAPEUTIC AREA LEAD OR GROUP LEADER (Senior Scientist/Principal Scientist)* *http://jobs.gene.com/00451607 <http://jobs.gene.com/00451607>* *The Position* The Clinical Pharmacology Department at Genentech, Inc. is seeking a Ph.D. level Senior Scientist or Principal Scientist who is driven to use pharmacometrics and system pharmacology approaches to advance the clinical development of novel drug candidates. As a strategic and scientific leader, this individual could act as Modeling and Simulation (M&S) Therapeutic Area Lead (TAL) or Group Leader (GL) depending on qualification. As the M&S TAL or GL, the individual will be responsible to oversee the strategy and implementation of the platform and project M&S in one or more therapeutic areas (such as Cancer Immunotherapy), and involve Clinical Pharmacology TAL or GL as needed for their respective TAs. The M&S activities include population PK/PD models, translational models, PBPK, systems pharmacology models, disease models, clinical trial simulations, literature meta-analysis, and other state of the art modeling and simulation techniques. Other key responsibilities are to establish close relationship with cross-functional key stakeholders (eg. functional leaderships, TA leads, and governance committee reviewers etc.), to serve as reviewer for relevant clinical or regulatory documents (eg. M&S reports, IND, End-of Phase 2 meeting, EU Scientific Advice meeting, BLA, NDA, sNDA, sBLA, etc.) and at relevant review forums (PKRF/OBRF/DxRF/DSRG/DRC), and as a member of the M&S Leadership Team (MSLT) or the Clinical Pharmacology Leadership Team (CPLT) as relevant with organizational responsibilities. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions on project teams. As M&S TAL or GL, the individual will contribute to planning and managing M&S resources and forecasting for the corresponding TAs. Qualified candidate will also be responsible to manage a group of scientists via direct and/or matrix management system. *Who You Are* EDUCATION: A Ph.D. in Pharmacometrics, Pharmaceutical Sciences, Biomedical or Chemical Engineering, Biostatistics, Applied Mathematics or Physics, or related discipline 7+ years (for Senior Scientist) or 15+ years (for Principal Scientist) of industry, regulatory, and/or related post-doctoral Modeling and Simulation experience is required. REQUIREMENTS: Candidates should have solid expertise in quantitative pharmacology, strong hands-on modeling and simulation skills, and demonstrated impact on drug development through quantitative approaches. Rich hands-on experience with NONMEM, SPLUS, R, Simcyp, GastroPlus, SimBiology, and/or other modeling and simulation software is required. Working experience with mechanistic PK/PD and/or system pharmacology modeling will be highly preferred. The candidate must have excellent communication and interpersonal skills and the ability to work independently and effectively on interdepartmental project teams. People management experience is highly desired. Experience in interaction with global regulatory agencies is a plus. The candidate must have strong leadership skills and the ability to influence. Candidate for the M&S Group Leader role must have proven track record of strong strategic leadership and people management skills in a fast-paced multi-tasked matrix environment. *PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY MODELER (Associate Scientist/Scientist/Senior Scientist)* *http://jobs.gene.com/00451478 <http://jobs.gene.com/00451478>* *The Position* The Clinical Pharmacology Department at Genentech, Inc. is seeking Ph.D. level Associate Scientist, Scientist, or Senior Scientist who is driven to use quantitative approaches to advance the clinical development of novel drug candidates. This individual will be responsible for the development and implementation of the platform and project Modeling and Simulation (M&S) strategy, in order to ensure that the right drug is administered to the right patient at the right dose and regimen. The modeling and simulation activities include population PK/PD models, translational models, PBPK, systems pharmacology models, disease models, clinical trial simulations, literature meta-analysis, and other state of the art quantitative techniques. Candidate specialized in quantitative systems pharmacology (QSP) M&S will be responsible for the development and integration of a variety of mechanistic modeling of biological systems, including models of intracellular signaling pathways, cell networks dynamics, disease models, and mechanistic PK/PD models, in the context of specific molecule or therapeutic area needs to support clinical trials such as dosing, patient selection, biomarker and diagnostic investigation, combination therapy identification and optimization. Key technical responsibilities are to organize, execute, and report Pharmacometrics and/or Systems Pharmacology M&S independently, as well as to present work at cross-functional teams, department meetings, senior management review committees, regulatory interactions, and scientific conferences. Other responsibilities will include planning, writing, and reviewing relevant clinical documents such as study protocols, analysis plans, reports, and regulatory documents. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, and other functions on project teams. Qualified individual could be responsible for overseeing the strategy and implementation of Pharmacometrics and Systems Pharmacology M&S by other scientists across projects. *Who You Are* EDUCATION: A Ph.D. in Pharmacometrics, Biomedical or Chemical Engineering, Biostatistics, Applied Mathematics or Physics, Pharmaceutical Sciences, or related discipline with 0+ year (for Associate Scientist), 3+ years (for Scientist), 7+ years (for Senior Scientist) of industry, regulatory, and/or related post-doctoral Modeling and Simulation experience is required. REQUIREMENTS: Candidates should have solid expertise in quantitative pharmacology and strong hands-on modeling and simulation skills. Demonstrated impact on drug development through quantitative approaches is highly desired. Rich hands-on experience with NONMEM, SPLUS, R, Simcyp, GastroPlus, SimBiology, and/or other modeling and simulation software is required. Experience with clinical trial simulation, optimal design, advanced mechanistic PK/PD and/or system pharmacology modeling is highly preferred. Experience in interaction with regulatory agencies is highly desired. The candidate must have excellent communication and interpersonal skills and the ability to work independently and effectively on interdepartmental project teams. The candidate must have strong leadership skills and the ability to influence. People management experiences are a plus.