Dear NMusers,
I'm having trouble writing the code for my model. I have IV and IP administrations data, that I would like to model simultaneously. We found out that IP was best modeled by a first order absorption, using an input compartment (DADT(1)=-KA*A(1)). At first, we used a CMT column in the dataset to indicate for each dosing event if it is IV or IP. But then, as we made the model more complicated, we realized that we couldn't use a CMT column. We study the parent compound, as well as its metabolite at the same time but the problem is we cannot put a compartment number for the metabolite's observations. This is because, given the model structure, the prediction for the metabolite concentrations is a sum of 3 concentrations in 3 different compartments (e.g. IPRED=A(6)+A(7)+A(8)). So we think that putting a compartment number for the observation would be confusing for NONMEM. What do you think? Do you see how we could model IV and IP simultaneously, without using the CMT column ? or any other solution? Thank you for your help Fanny Gallais
