Dear NMusers,
I have a question regarding IOV modelling. I have a cohort of patients to whom a drug is given on 3 days consecutive for 3 cycles (with 21-day interval). Blood samples are taken on each of the 3 days whithin each cycle. I would like to know if there is a way to code simultaneously the inter-day and inter-cycle variability of any PK parameter of interest (Clearance in our study). In other words, a way to have two levels of IOV ? Thanks a lot for any answers or suggestions! Warm regards, Sotheara MOEUNG
