A popular from of Hormone Replacement Therapy (HRT), whichis often used
to stave off the changes associated with female aging, canaccelerate
hearing loss. University of Rochester <http://www.rochester.edu>  
researchers led by Robert D.Frisina
<http://www.urmc.rochester.edu/GEBS/faculty/Robert_Frisina.htm>   found
that women who were taking a combination of estrorogen and progestinehad
hearing deficits typically expected in women five to 10 years older.
Thestudy of 124 women between the ages of 60 and 86 points to progestine
as theculprit, because the hearing of participants who took estrogen
alone wasunaffected by the treatment.



Previous studies have also documented slight hearing loss inwomen taking
birth-control pills containing progestine and in younger womenduring the
stage of their menstrual cycles when progesterone, the
hormone'snatural form, is at its highest level. Yet women still have
better overallhearing than men up until menopause, a benefit attributed
to natural estrogen.



Frisina thinks that the progestine-induced damage detectedin the study
may arise when nerve cell membranes are exposed to a
progestinemetabolite, allopregnanolone: the cells become less excitable,
or responsive,to stimulation. If that is the mechanism at work, then the
nerve cells in theHRT group with hearing loss may be dampened but not
dead, suggesting that theeffect is reversible. Frisina's group plans
to study next what happens towomen's hearing when they stop HRT.



Frisina would like to see drug companies perform similarsensory testing
during development of HRT products and release any results theymay
already have. "It might be valuable information," he says. In
the meantime,the hearing risk "Should be a part of the conversation
when a women and herdoctor discuss HRT," he adds, particularly for
women who already have hearingloss.




Happy Learning,




Yovan P. Putra <http://primamind.blogspot.com>

www.primastudy.com <http://www.primastudy.com>







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