In a cloud environment, cross_node_timeout = true can cause issues; we had this 
issue in our environment and it is set to false now.
Dropped messages is an another issue

Subroto 

> On Jul 20, 2017, at 8:27 AM, ZAIDI, ASAD A <az1...@att.com> wrote:
> 
> Hello Folks –
>  
> I’m using apache-cassandra 2.2.8.
>  
> I see many messages like below in my system.log file. In Cassandra.yaml file 
> [ cross_node_timeout: true] is set and NTP server is also running correcting 
> clock drift on 16node cluster. I do not see pending or blocked HintedHandoff  
> in tpstats output though there are bunch of MUTATIONS dropped observed.
>  
> <start timeout message >
> INFO  [ScheduledTasks:1] 2017-07-20 08:02:52,511 MessagingService.java:946 - 
> MUTATION messages were dropped in last 5000 ms: 822 for internal timeout and 
> 2152 for cross node timeout
> <end timeout message >
>  
> I’m seeking help here if you please let me know what I need to check in order 
> to address these cross node timeouts.
>  
> Thank you,
> Asad
>  

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