Of course, I solved it right after finally giving up and posting my question. 
My 4D email sending code has a safeguard in test mode to prevent accidentally 
sending emails to customers. So it was not using the "to" address I provided. 
In sandbox mode, SES requires both the sender and receiver addresses to be 
verified before you can use them.

John DeSoi, Ph.D.


> On May 21, 2018, at 9:47 AM, John DeSoi via 4D_Tech <[email protected]> 
> wrote:
> 
> Has anyone successfully used SES with 4D IC's SMTP commands? SMTP_Send always 
> fails with error code 10046 (SMTP 554 - Transaction failed). I'm using 
> 16.3HF2 Mac.
> 
> I know the SES SMTP interface is working because I can send emails from the 
> same computer using PHP.

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