My experience with doing this is that it only worked about 1 in 5 
times.  I've tried it at least 5 times and only once did I get the new 
PC to boot.  After booting I had to spend about 2 hours cleaning up 
device manager and getting the correct drivers installed.  The other 
times the PC simply wouldn't boot - either it would continually freeze  
shortly after POST, or it would freeze immediately after POST showing 
nothing but a blank screen.

So, I would say that it's worth a try, but don't get your hopes up too 
high.  I think your best bet is to go into Device Manager immediately 
before your final shutdown, and uninstall some of the drivers - such as 
Display and Audio adapters, and network adapters. Then shutdown and do 
the move.  When you first boot the new PC, if it freezes, try rebooting 
into Safe Mode (continually tap F8 during boot).  Then maybe you can do 
some more cleaning up in Device Manager.
Hopefully it will not choke when it finds all the strange new devices 
and will install some of the new drivers for you.
The product key will be the least thing to worry about - you can deal 
with that after you get all the drivers installed and the PC working 
correctly.  Sometimes Windows won't even complain that you're on a new 
machine (especially if you're on an older version of windows), and even 
if it does a simple call to Microsoft will fix it.

Wishing you luck!  If you get a chance... post back and let us know how 
it went.   :-)

Donk

On 6/4/2013 11:16 AM, ger_ila wrote:
> Hi,
>    
> just wondering if it's possible to take a hdd, loaded with o/s, from one PC 
> and use it in another PC, different make, as primary (only) drive. I 
> understand it's the boot files that present the problem, but how is it 
> overcome? Obviously the product key would need changing.
>
>
>
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