Bio-engineered pig corneas helping to restore vision in China


http://www.thehindu.com/news/international/bioengineered-pig-corneas-helping-to-restore-vision-in-china/article8348712.ece?utm_source=RSS_Feed&utm_medium=RSS&utm_campaign=RSS_Syndication


Forty-seven patients who received the transplant at Wuhan Union Hospital have 
fully recovered their eyesight, said Mr. Zhang.
Bio-engineered corneas made from pigs’ eyes in China may help millions of 
patients to see again, ophthalmologists have said.
A 14-year-old boy regained his sight after receiving a pig cornea transplant on 
February 25, said Yuan Jin of Sun Yat-sen University ophthalmology centre in 
the southern Chinese city of Guangzhou.
The boy had injured his right eye with a firecracker during New Year 
celebrations.
“He developed ulcer in his right eye and had lost his sight before the 
transplant. A week after the transplant, he had regained some vision. In the 
future his sight may be close to normal,” Mr. Yuan told state-run Xinhua news 
agency.
The cornea is the eye’s outermost transparent layer.
Every year, more than five million Chinese patients are blinded by cornea 
disorders or damage.
The demand for cornea transplants far exceeds supply, so bio-engineered 
solutions could restore the eyesight of millions of Chinese, Mr. Yuan said.
Research into the use of animal corneas began in 2003 at Ainier Cornea 
Engineering Company, Shenzhen and the Fourth Military Medical University, Xi’an.
After success in animal tests, clinical tests were carried out in 2010 on 100 
patients in four hospitals in Beijing and Wuhan, with 94 patients regaining 
some or all of their vision.
Pig corneas proved just as successful as human, Zhang Mingchang, director of 
ophthalmology at Wuhan Union Hospital said.
Forty-seven patients who received the transplant at Wuhan Union Hospital have 
fully recovered their eyesight, said Mr. Zhang.
Artificial corneas are not a miracle cure for all disorders, however, they 
cannot help, for example, with severe penetration wounds.
Zhang Bin, director of Ainier Cornea, said initial trials were conducted using 
tissue from chickens, cows, ducks, geese, monkeys and sheep before pigs were 
selected.
Some corneas may carry viruses and pig tissue was found to have the lowest risk 
of infection in the recipient.
The bio-mechanical properties of human and pig corneas are very similar, he 
said.
The company gained China Food and Drug Administration approval in April last 
year for “Acornea,” the first such commercial product to be accredited, and it 
has since gone into mass production.
“It takes 20 days of quite complex processes from removing the tissue from the 
donor to produce one Acornea,” Mr. Zhang added. 




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