The Hindu News Update Service
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News Update Service
Wednesday, October 1, 2008 : 0300 Hrs       

Health
Corneal reconstruction tech a boon to acid attack victims 

Madurai (PTI): Victims of acid attacks who lost their vision can now look 
forward to regain their eyesight, thanks to the breakthrough in corneal 
reconstruction
technology under which lost stem cells could be restored. 

If cornea becomes opaque due to burn injury or accidental splashing of acid, 
there is hope for getting back vision by corneal reconstruction technology,
Director (Research) of Aravind Medical Research Foundation, Dr V.R. 
Muthukaruppan told PTI. 

"Cornea becomes opaque because of the burning of stem cells. Now a definitive 
method of identifying and quantifying corneal epithelial stem cells had been
established," Chief of the Department of Medical Education of the foundation Dr 
N.Venkatesh Prajna said. 

"If one eye is not affected, we can take out stem cells from that eye and can 
use them for reconstruction of the affected cornea. The method has been found
to be a success in the case of a patient," Muthukaruppan said. 

"In case of people whose both eyes suffer from stem cell deficiency, a new 
method has been invented in which a small piece of oral epithelium is 
cultivated,"
he said, adding that this procedure has provided substantial vision to a 
patient. 

"All this is being done for the first time. Now we are in the process of 
understanding the factors of molecular mechanism required for converting oral to
corneal epithelium," he said. 

Dr Muthukaruppan said another major research was to identify the cause of 
granuloma (accumulation of white blood cells and fibrous tissue) on the eye 
surface.


What was considered, for a long time as tubercular infection, was now found to 
be due to a worm especially in children who take bath in ponds of certain
villages in Thanjvur, Tiruvarur and Nagapattinam districts in Tamil Nadu. 

"We have developed a simple treatment to excise the granuloma for quick and 
complete recovery, rather than a long anti-tubercular treatment," he said. 

Though well established method of cataract surgery by implanting intraocular 
lens had been developed,about 10 per cent of the patients developed reduced
vision due to Posterior Capsular Opacification (PCO), he said. 

The university of Wisconsin, USA is collaborating with the Aravind research 
foundation in establishing a culture method using cadaver donor lens capsule
to screen for drugs which would prevent formation of PCO. 

Describing Glaucoma as a silent eye disease, he said by the time symptoms 
developed, it becomes too late to treat for recovery of the lost vision. 
Therefore
it is essential to identify plasma marker so that diagnosis of patients could 
be established much earlier than the development of symptoms. 

The Department of Biotechnology and the Cole eye institute of USA are 
collaborating with the foundation on this research. 


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