Hindu news update service:

Stem cells restore sight, almost miraculously

Sydney (IANS): Stem cells cultured by researchers on a simple contact lens 
miraculously restored sight to sufferers of blinding corneal disease.

The simple and inexpensive procedure, considered a breakthrough, requires a 
minimal hospital stay and significantly improves vision within weeks.

University of New South Wales (UNSW) researchers from its School of Medical 
Sciences harvested stem cells from patients' own eyes to rehabilitate the 
damaged
cornea.

The stem cells were cultured on a common therapeutic contact lens which was 
then placed onto the damaged cornea for 10 days, during which the cells were
able to re-colonise the damaged eye surface.

While the novel procedure was used to rehabilitate damaged corneas, the 
researchers say it offers hope to people with a range of blinding eye conditions
and could have applications in other organs.

The trial was conducted on three patients; two with extensive corneal damage 
resulting from multiple surgeries to remove ocular melanomas (a cancer of the
eye), and one with the genetic eye condition aniridia.

Other causes of cornea damage can include chemical or thermal burns, bacterial 
infection and chemotherapy.

"The procedure is totally simple and cheap," said study author, UNSW's Nick Di 
Girolamo. "Unlike other techniques, it requires no foreign human or animal
products, only the patient's own serum, and is completely non-invasive.

"There's no suturing, there is no major operation: all that's involved is 
harvesting a minute amount - less than a millimetre - of tissue from the ocular
surface," Mr. Di Girolamo said.

"If you're going to be treating these sorts of diseases in third world 
countries all you need is the surgeon and a lab for cell culture. You don't need
any fancy equipment."

Because the procedure uses the patient's own stem cells harvested from their 
eye, it is ideal for sufferers of unilateral eye disease. However, it also
works in patients who have had both eyes damaged, Mr. Di Girolamo said, 
according to an UNSW release.

"If we can do this procedure in the eye, I don't see why it wouldn't work in 
other major organs such as the skin, which behaves in a very similar way to
the cornea," Mr. Di Girolamo said.

These findings appeared in the journal Transplantation this week.

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Rajesh Asudani

Manager
Reserve Bank of India
Nagpur
09420397185
O: 0712 2806676
Res: 0712 2591349
Doth God exact day-labour, light denied?"
John Milton


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