Feb 21st 2015
http://www.economist.com/news/science-and-technology/21644122-new-device-may-restore-vision-those-whose-sight-dwindling-bionic-eyes
MACULAR degeneration is a form of sight loss caused by the death of
photoreceptor cells in the macula--the central part of the retina. It
afflicts 30m-50m people, most of them elderly. The result is a
shadowlike void in the centre of a sufferer's visual field. Many
solutions have been proposed, from injecting a patient's eyes with
stem cells that will grow into new photoreceptors to building small
telescopes into spectacles or contact lenses.

Another is to implant a light-sensitive chip in the affected part of
the retina--a promising idea in principle, but one that has not worked
well in practice. Daniel Palanker of Stanford University thinks he can
do better. He has developed a chip-based system which, although it
will not fully restore vision, may bring someone back to a point where
he is no longer legally blind.

Dr Palanker's apparatus, currently being tested on rats, but intended
for clinical trials on people within a year, has two parts. One is a
special pair of glasses. The other is not a single photosensitive
chip, but a set of them.

The spectacles let light into the eye as normal, so that unaffected
bits of the retina can continue to do their job. But they also use a
small camera to capture the scene the wearer is looking at. That image
is then beamed through the pupil of the affected eye to the part of
the retina where the chips are. The retransmitted image is 1,000 times
brighter than the one created by natural light, but because it is sent
in the infra-red part of the spectrum, the eye's photoreceptor cells
cannot see it.

The chips, however, can. Each of them is 1mm across, and is covered
with elements 75 microns (millionths of a metre) wide that are made of
three photosensitive diodes and two electrodes. When hit by infra-red
light, the diodes generate an electric current and, via the
electrodes, stimulate nerve cells in the retinal tissue in the way
that a natural photoreceptor would. That signal gets sent to the
brain. The result is a picture which fills in the blank part of the
user's visual field.

The chips themselves are easy to implant, using a special syringe-like
applicator that is pushed through the eyeball (a routine procedure,
gruesome though it sounds). With this tool members of Dr Palanker's
team can "tile" the affected area with as many chips as is necessary.

Unlike some existing chip systems, this one does not need an external
power supply (though the glasses themselves need batteries). It also
has better resolution than its competitors. Although 75 microns is
still a bit coarse, Dr Palanker hopes to improve it soon, to 40
microns. The definition of legal blindness in America corresponds to
the resolving power that elements 50 microns across or smaller would
give, so in that sense the device really would restore sight to the
blind. Experiments on rats, in which they are shown alternating black
and white lines of different widths, suggest that the theoretical
resolution is actually being achieved. If clinical trials show the
same is true in people, Dr Palanker's invention may go on to bring
visual relief to many whose eyesight is failing.

-- 
Avinash Shahi
Doctoral student at Centre for Law and Governance JNU



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