We've use a seperate xml file for all system settings that we don't want in the DB including the UserID, password and datasource. The whole file is encrypted. What we like about this is all we have to do is just one change and the whole system is updated. The location of this file is in the app config. If you want to change the settings just for one user, we have an app that can generate do that (change the settings and store them locally, change the app config). I wrote the xml file loading and decryption years ago and have used it many many times so I love the reuse I've gotten on my work. Just plug and play :)
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