-----Original Message-----
From: "Hiten Raja" <[email protected]>
Sender: [email protected]
Date: Thu, 19 May 2011 17:46:28 
To: b. Chumma de de<[email protected]>
Subject: Chumma:*) Embryo Frozen for 20 Years Is Now a Bouncing Baby Boy






Embryo Frozen for 20 Years Is Now a Bouncing Baby Boy



A frozen embryo like this one was created in 1990, but brought to term by a 
different woman in 2010.

Imagine being born at the age of 20. Doctors at the Jones Institute for 
Reproductive Medicine in Virginia have made history by implanting a 20 year old 
frozen embryo and having it successfully brought to term. An unnamed 42 year 
old woman gave birth to the healthy baby boy in May, and the work was recently 
discussed in the Journal of Fertility and Sterility. The embryo was donated by 
a couple that had used in vitro fertilization (IVF) back in 1990. Amazingly, 
that means the new baby boy has at least one 20 year old sibling out in the 
world that was conceived at the same time. According to The Telegraph, the 19 
year 7 month old frozen embryo beat the previous record of 13 years, but 
theoretically they could be preserved much longer - perhaps indefinitely. The 
long term storage and use of reproductive materials is enabling a strange sort 
of genetic immortality, as well as generating a new era of conflict as frozen 
eggs, sperm, and embryos are fought over in divorces and disputed between 
donors and recipients. IVF has been changing reproduction in the world for 
decades, but it's only now, with the long term viability of these materials 
becoming more relevant, that we are beginning to understand some of its 
implications.

The Jones Institute for Reproductive Medicine was a fitting location for the 
record breaking frozen embryo implantation as it was where the first IVF was 
performed in the United States in 1981. Initially I wondered if the use of such 
an aged embryo was actually a bit of publicity stunt, as the JI does dedicate 
quite a bit of time on their site discussing and pointing to the 'firsts' at 
their facility. Yet it appears the 20 year old embryo was simply the one 
available to the patient. As they have a practical shelf life extending well 
into decades, we are likely to see many more of these older genetic materials 
finding use. After all, once it is made the only real options for a frozen 
embryo are to be implanted, donated to science, or destroyed. (The US culture 
seems to frown on the latter two, so the first is a stronger possibility.)

I say 'embryo' in the singular, but really of course, frozen embryos are almost 
always created in groups. For the record 20 year implantation, 5 embryos were 
thawed, 2 survived and cleaved, and one reached full term (not sure if this was 
due to selection or not). With those kinds of odds, couples looking to use IVF 
typically have to create many embryos, and extras often end up frozen. The 
result is what we've seen here: extraneous genetic material in long term cold 
storage is finding use decades after creation.

The implications may be farther reaching than we realized when we began the IVF 
business. There are legal issues of course: who owns genetic material that a 
couple creates together after they separate? Is abandoned genetic material fair 
game? Who owns it after someone dies? The last presents perhaps the most 
intriguing possibility: we may have the means to create someone's child years 
(decades) after they die. You could, theoretically, freeze an embryo today, and 
have your living descendants bring it to term a hundred years from now. It's a 
strange genetic immortality.

And not so far from what's already happened. The Telegraph mentions a mother 
who froze her eggs for her daughter, who has a reproductive illness, so that 
the daughter can have children when she is an adult. Giving birth to a half 
sibling sounds insanely incestuous, but I'm sure we'll see weirder combinations 
of families as frozen genetic materials continue to survive.

We may find a way to extend our lives well past the centennial mark as we 
discover more of the secrets of aging. Yet women, and many men, will be unable 
to produce offspring once they reach their later years. The current popularity 
of IVF is, in some part, a necessity due to many couples waiting longer to have 
kids. What happens when "50 is the new 20?? Science may keep us young and 
healthy, but our eggs and sperm won't have our youthful zest. Will we save our 
genetic material for use later? Thousands already do. Imagine a world where a 
large number of us freeze our eggs and embryos so we can wait to have kids 
until our late forties. All those unused frozen eggs, sperm, and embryos. they 
may be donated to couples who didn't plan ahead, maybe even used by offspring 
who want to 'recreate' an ancestor from the past. When our genetic materials 
can last nearly forever, the possible outcomes grow more and more 
extraordinary. Twenty years for a frozen embryo is a record for now, but 
someone is bound to break it. Perhaps when they do it will be in a future where 
giving birth to someone decades after they were conceived won't be that 
remarkable at all.


jckrsna
Yours
Hiten A. Raja
Nairobi.
KENYA. 

[email protected]


In the 60's, people took acid to make the world weird.  Now the world is weird 
and people take Prozac to make it normal. 

Politics is supposed to be the second oldest profession. I have come to realize 
that it bears a very close resemblance to the first. 

Do you ever wonder why you gave me your email address.

Health nuts are going to feel stupid someday, lying in hospitals dying of 
nothing. 

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