The Micro Lisa: Incredible 'molecular painting' of masterpiece that is
three times narrower than a HUMAN HAIR

   - The tiny picture is 'painted' on a substrate that is just 30 microns
   in width using tiny chemical reactions
   - American scientists controlled the number of new molecules created -
   the greater the heat, the darker the shade of grey
   - Researchers at the Georgia Institute of Technology believe 'Mini Lisa'
   demonstrates a technique that could be used in nanomanufacturing

By Sarah 
Griffiths<http://www.dailymail.co.uk/home/search.html?s=&authornamef=Sarah+Griffiths>
 *PUBLISHED:* 10:00 GMT, 6 August 2013 | *UPDATED:* 11:52 GMT, 6 August 201


American scientists have recreated the world's most famous painting on the
world's smallest canvas, which measures just 30 microns in width.
The Mona Lisa, originally painted by Leonardo da Vinci, has now been
'painted' on a substrate measuring one third of the width of a human hair,
using tiny chemical reactions.
The scientists believe 'Micro Lisa' demonstrates a technique that could
potentially be used to achieve nanomanufacturing of devices as they were
able to vary the surface concentration of molecules on such short-length
scales.
 [image: Georgia Tech researchers have created the 'Mini Lisa' on a
substrate surface approximately 30 microns in width]
Researchers from the Georgia Institute of Technology have created the 'Mini
Lisa' on a substrate surface approximately 30 microns in width. The image
demonstrates a technique that could potentially be used to achieve
nano-manufacturing of devices
 [image: The Mona Lisa by Leonardo da Vinci, which is the best known and
most parodied painting in the world]
The Mona Lisa by Leonardo da Vinci, which is the best known and most
parodied painting in the world
 The famous image was re-created with an atomic force microscope and a
process called ThermoChemical NanoLithography (TCNL).
Going pixel by pixel, scientists at the Georgia Institute of Technology
positioned a heated cantilever at the substrate surface to create a series
of confined nanoscale chemical reactions.

By varying only the heat at each location, PhD Candidate Keith Carroll
controlled the number of new molecules that were created - the greater the
heat, the greater the local concentration.
More heat produced the lighter shades of grey, as seen on the Mini Lisa's
forehead and hands.
Less heat produced the darker shades in her dress and hair, which can be
seen when the molecular canvas is visualised using fluorescent dye. Each
pixel is spaced by 125 nanometers.
Jennifer Curtis, an associate professor in the School of Physics and lead
author of the study that was published in journal Langmuir, said: 'By
tuning the temperature, our team manipulated chemical reactions to yield
variations in the molecular concentrations on the nanoscale.
'The spatial confinement of these reactions provides the precision required
to generate complex chemical images like the Mini Lisa.'
 [image: The famous image was re-created with an atomic force microscope]
The famous image was re-created with an atomic force microscope (pictured)
and a process called ThermoChemical NanoLithography (TCNL). Going pixel by
pixel, scientists positioned a heated cantilever at the substrate surface
to create a series of confined nanoscale chemical reactions
Production of chemical concentration gradients and variations on the
sub-micrometre scale are difficult to achieve with other techniques.
The scientists produced chemical gradients of amine groups, but expect the
process could be extended for use with other materials.
Professor Curtis said: "We envision TCNL will be capable of patterning
gradients of other physical or chemical properties, such as conductivity of
graphene.
 [image: Professor Curtis (pictured) said technique should enable a wide
range of previously inaccessible experiments]
Professor Curtis (pictured) said technique should enable a wide range of
previously inaccessible experiments and applications in fields as diverse
as nanoelectronics, optoelectronics and bioengineering
'This technique should enable a wide range of previously inaccessible
experiments and applications in fields as diverse as nanoelectronics,
optoelectronics and bioengineering.'
She said another advantage is that atomic force microscopes are fairly
common and the thermal control is relatively straightforward, making the
approach accessible to both academic and industrial laboratories.
To facilitate their vision of nano-manufacturing devices with TCNL, the
Georgia Tech team has recently integrated nanoarrays of five thermal
cantilevers to accelerate the pace of production.
Because the technique provides high spatial resolutions at a speed faster
than other existing methods, even with a single cantilever, Professor
Curtis is hopeful that TCNL will provide the option of nanoscale printing
integrated with the fabrication of large quantities of surfaces and
everyday materials, whose dimensions are more than one billion times larger
than the TCNL features themselves.





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