So... which drugs stimulate the mediodorsal thalamus? Maybe I have taken
them accidentally before. I've sampled just about anything.

On Thu, 1 Aug 2019 at 18:49, Alan Grimes via AGI <[email protected]>
wrote:

> The cortical algorithm is interesting. Cortical columns are pretty sexy
> too because they're an obvious target for finding a high level algorithm
> that does the same or better.
> 
> But regardless of how you implement cortex, the next thing you MUST do
> to achieve a full functioning mind is to implement the actual structure
> for sequential thought, not just a logic network (like a deep learning
> model), but actual sequential thinking. It also seems that the brain can
> do basic task switching, in that multiple symbols can be fit into the
> pipeline and operate in sequence.?? I think the synchronization and
> buffering is done by the basal ganglia.
> 
> In the brain, that structure is the Cortico-thalamo-Cortical loop. Any
> functioning AGI architecture will have something similar.
> 
> There are several things going on, one is basic feedback, ie feedback
> applied to an input circuit will squelch out parts of the input that the
> brain has already perceived so that new information is highlighted.
> 
> Sometimes brain regions generate activity spontaneously and information
> is encoded by inhibiting some of those spontaneous signals. So yeah,
> there is a lot of information to grok but it's all important if you want
> to sucessfully make a functioning AGI.
> 
> Another thing is disinhibition, where a brain region might have
> inhibitory projections but if it, itself, is inhibited, that is removing
> that inhibition to the ultimate target, so it becomes disinhibited and
> available to either spontaneous firing or stimulated firing.
> 
> (many neurons have a base rate of spontaneous firing that can either be
> excited or inhibited.)
> 
> Quote from page on Thalamus linked below:
> Recent research suggests that the mediodorsal thalamus may play a
> broader role in cognition. Specifically, the mediodorsal thalamus may
> "amplify the connectivity (signaling strength) of just the circuits in
> the cortex appropriate for the current context and thereby contribute to
> the flexibility (of the mammalian brain) to make complex decisions by
> wiring the many associations on which decisions depend into weakly
> connected cortical circuits."[31] Researchers founds that "enhancing MD
> activity magnified the ability of mice to ???think,???[31] driving down by
> more than 25 percent their error rate in deciding which conflicting
> sensory stimuli to follow to find the reward." [32]
> 
> REALLY?!??!!??!???? YOU THINK?!??!?!!?? I mean like wow, you must be like
> Sherlock Holms and Albert Einstein rolled together, I mean who would
> have thought a piece of anatomy that was basically wired into just about
> every part of the brain and was part of the major signal/information
> flows into and through the brain could have such a role!!!!
> 
> Seriously though, this is how the brain selects which networks it needs
> to accomplish specific functions and implements multiple behaviors (ie
> general intelligence) instead of just mastering one simple domain such
> as an Atari game or something.
> 
> https://en.wikipedia.org/wiki/Cortico-basal_ganglia-thalamo-cortical_loop
> 
> https://en.wikipedia.org/wiki/Thalamus
> 
> https://en.wikipedia.org/wiki/Basal_ganglia
> 
> Anyway, this post is part of a series I'm doing on neural anatomy, I
> already have my topic picked out for tomorrow, not sure what else I
> should cover, feel free to make requests...
> 
> --
> Clowns feed off of funny money;
> Funny money comes from the FED
> so NO FED -> NO CLOWNS!!!
> 
> Powers are not rights.
> 


-- 
Stefan Reich
BotCompany.de // Java-based operating systems

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