Hi everyone,
Thank you so much for your great responses.

Below is a sum of a SUM on what I got. But first, here's my original
question.

ORIGINAL QUESTION:
Hi list members,

I am new to geo/spatial statistics and I don't have any expert spatial
epidemiologist in my country. So I thought I'd run through what I have done
with you all, and check whether I am on the right track. If anyone has any
better ideas, please feel free to let me know too!

I am working on the following questions:
How can I test the hypothesis that most of the dengue cases are located
where most of the population are?
How can I test the hypothesis that significantly more dengue cases are
located in the east than in the west of my country?
How can I detect if there are any clustering or any other spatial trends of
dengue in relation to population?

In my Arcview GIS 3.2, I have a polygon layer of population according to
postal sectors (83 polygons with sizes ranging from 0.3 km(superscript: 2)
to 33 km(superscript: 2)). I also have a point layer of dengue cases.

What I've done so far:
   Correlated number of dengue cases with population in each postal sector
   polygon.
   Correlated number of dengue cases with population density (i.e.
   population/ area) in each postal sector.
   Correlated dengue morbidity rate (i.e. no. of cases/ population) with
   population in each postal sector.
   Correlated dengue morbidity rate with population density in each postal
   sector.

What more can I do?

Thanks very much in advance. Best wishes.

Basil
Vector Control & Research Dept
Singapore


----- Forwarded by Basil LOH/ENV/SINGOV on 16-07-2001 09:15 -----
                                                                                       
       
                    Nicholas                                                           
       
                    Lewin-Koh               To:     Basil LOH/ENV/SINGOV@SINGOV        
       
                    <[EMAIL PROTECTED]        cc:                                        
       
                    us.edu.sg>              Subject:     Re: AI-GEOSTATS: Dengue & 
population 
                                                                                       
       
                    13-07-2001 22:31                                                   
       
                                                                                       
       
                                                                                       
       




On Fri, 13 Jul 2001 [EMAIL PROTECTED] wrote:
Hi,
Actually there are a few of us here at NUS.

>
> Hi list members,
>
> I am new to geo/spatial statistics and I don't have any expert spatial
> epidemiologist in my country.

Actually there are a few of us here at NUS.

> I am working on the following questions:
> How can I test the hypothesis that most of the dengue cases are located
> where most of the population are?
> How can I test the hypothesis that significantly more dengue cases are
> located in the east than in the west of my country?
> How can I detect if there are any clustering or any other spatial trends
of
> dengue in relation to population?

What you are looking for is tests of case clustering and small area
estimation.
There is a very nice package for R (or Splus if available) called Splancs
that has a lot of the procedures you might be looking for.

You might want to
a) test for significant clusters of Dengue cases.
b) Fit a Spatial poisson model on the counts of dengue per postal area
(probably over dispersed due to lots of 0's)

c) test environmental covariates against incidence

d) fit a model to determine risk of contracting the disease (hazard rate)

You have the luxury of using either point pattern type approaches or
lattice models on the postal areas.

You can call me if you want more advice at
874-6559

Nicholas

 >
> In my Arcview GIS 3.2, I have a polygon layer of population according to
> postal sectors (83 polygons with sizes ranging from 0.3 km(superscript:
2)
> to 33 km(superscript: 2)). I also have a point layer of dengue cases.
>
> What I've done so far:
>    Correlated number of dengue cases with population in each postal
sector
>    polygon.
>    Correlated number of dengue cases with population density


                 CH3
                  |
                  N             Nicholas Lewin-Koh
                 / \            Dept of Statistics
           N----C   C==O        Program in Ecology and Evolutionary Biology
          ||   ||   |           Iowa State University
          ||   ||   |           Ames, IA 50011
          CH    C   N--CH3      http://www.public.iastate.edu/~nlewin
            \  / \ /            [EMAIL PROTECTED]
             N    C
             |   ||             Currently
            CH3   O             Graphics Lab
                                School of Computing
                                National University of Singapore
     The Real Part of Coffee    [EMAIL PROTECTED]

----- Forwarded by Basil LOH/ENV/SINGOV on 16-07-2001 09:15 -----
                                                                                       
    
                    "Richard M                                                         
    
                    Webb"                To:     Basil LOH/ENV/SINGOV@SINGOV           
    
                    <rmwebb@usgs.        cc:                                           
    
                    gov>                 Subject:     Re: AI-GEOSTATS: Dengue & 
population 
                                                                                       
    
                    14-07-2001                                                         
    
                    00:07                                                              
    
                                                                                       
    
                                                                                       
    



Basil,

I hope the following reference can offer you some guidance and/or ideas.

Morrison, A.C., Santiago, Marilyn, Rigau-P�rez, J.G., and Reiter, Paul,,
1998, The
     Transmission of Dengue fever in Puerto Rico: an epidemiologic approach
using a
     geographic information system: U.S. Geological Survey Water-Resources
     Investigations Report 98-4119, 86 p.

Regards,

Rick Webb

************************************************************
Richard MT Webb
USGS, WRD                          Telephone: 303-236-5025
Box 25046, MS 413, DFC             Fax:       303-236-5034
Denver, CO 80225-0046              Email: [EMAIL PROTECTED]
************************************************************


* To post a message to the list, send it to [EMAIL PROTECTED]

----- Forwarded by Basil LOH/ENV/SINGOV on 16-07-2001 09:15 -----
                                                                                       
           
                    "Richard Hoskins"                                                  
           
                    <[EMAIL PROTECTED]        To:     <[EMAIL PROTECTED]>     
           
                    >                           cc:                                    
           
                    Sent by:                    Subject:     RE: Dengue & population   
           
                    [EMAIL PROTECTED]                                               
           
                    ington.edu                                                         
           
                                                                                       
           
                                                                                       
           
                    14-07-2001 03:49                                                   
           
                    Please respond to                                                  
           
                    waphgis                                                            
           
                                                                                       
           
                                                                                       
           




Basil: I think one very effective way to  get the information you need is
to
use a spatial scan statistic approach. Your data is made for it. You do not
need to test the hypothesis of E vs W, and of course

likely, there are more cases where there are more people - I suspect the
mossies like areas where
there is lots of food(people).
I think you need to know where the rates are higher than anywhere else, if
the idea is to deal with those areas first.
Also it can tell you where areas are lower than expected and give an easy
to
understand way to determine if the rates are really elevated or not.

The spatial scan statistic can be easily calculated. The background is
http://www.sph.umich.edu/~lestberg/GeoMed/Scan/ScMain.htm

http://sun2539.sph.umich.edu:2000/geomed/stats/kullscan/scan.html

http://sun2539.sph.umich.edu:2000/geomed/stathelp/advisor.html

http://dcp.nci.nih.gov/bb/SaTScan.html  has free software

and there is a commercial product now which does cluster calculations

http://www.terraseer.com/clusterseer.html  which has a whole lot of cluster
tests bundled in one place.

A link directly to ArcView  http://www.phrl.org/REGS/Order.htm

Dick Hoskins
WA State Dept of Health



-----Original Message-----
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED]]On Behalf Of [EMAIL PROTECTED]
Sent: Friday, July 13, 2001 1:36 AM
To: [EMAIL PROTECTED]; [EMAIL PROTECTED];
[EMAIL PROTECTED]; [EMAIL PROTECTED];
[EMAIL PROTECTED]
Subject: Dengue & population



Hi list members,

I am new to geo/spatial statistics and I don't have any expert spatial
epidemiologist in my country. So I thought I'd run through what I have done
with you all, and check whether I am on the right track. If anyone has any
better ideas, please feel free to let me know too!


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