Ed,

> I am a bit concerned about the performance of amavisd.
> The server will be lightly loaded and then I'll get a number of these
> deferrals. When there is a lot of traffic this can grow to several hundred.
> Also the amavis scanning is taking its sweet time.
> I have 2 front-end MX servers and 2-Outbound smtp servers. These servers
> are the content scanning servers. I originally had 2 but at peak hours they
> would run far behind. I have since then added 2 more servers for a total of
> 4. Mail traffic is about 150,452 per day averaging 6,200 per hour. Peaks
> are around 10,000 an hour. Average message size is 32K. During peak hours
> the average message size will be between 45K and 50K. Below are relevant
> postfix settings. I currently have bayes and auto white listing turned off.
> No extra rules other than the ones that come with the install. One of the
> servers I'm running 20 max servers, One of the other I'm running 7 max
> servers. Not much difference in problems with either server.

See diagrams and figures in:
  http://www.ijs.si/software/amavisd/amavisd-new-magdeburg-20050519.pdf

which may induce some ideas. You may also want to collect timing breakdown
(at log level 2) and make a report out of it. Averages are quote meaningless
with non-symmetrical distributions, look for median and say 10 and 90% 
quantiles.

Btw, you may want to add 'no_header_body_checks' to
  -o receive_override_options=no_unknown_recipient_checks
on smtpd at port 10025.

> What causes these refusal messages?

Like Noel said, looks like amavisd was restarted at 14h.

  Mark


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