Dear all

A query re samples to use for a reference pool - the bigger the
better?  I am not so certain.  I have looked at a number of similar
samples repeatedly, and as these samples have arrived over a period of
time, so my pool of normals has grown.  I have re-run a few analyses
altering the pool size, and the results are not always cleaner.  My
pool samples have all been run at the same place, however they are
very heterogeneous.  Does anyone have any thoughts/opinions on this?
Any suggested QC/plots to try and select the best reference samples
from my pool of ~100?  [N.B. these are 6.0 chips].

with thanks,

Lavinia Gordon.
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