Dear Group,

I have 28 samples of tumour normal pairs, run on 2 GenomeWideSNP6.0 arrays 
several months apart. Some of the pairs have members on different chips (ie 
tumor on one, normal on the other). I am not sure about the best way to 
normalise the data such that these split pairs can be used for downstream 
analysis. The plan is for ASCRMA, TumorBoost and then PSCBS.

I have applied ASCRMA to each array separately. Probe density plots pre and 
post this normalisation are attached. It seems that there is still some 
room for improvement.

Thank you and all the best for the new year.

Regards,
Peter

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