One paper (see below) concludes that Combined Altitude Depleted Oxygen
(CADO) is just as effective a tool for hypoxia awareness training as
hypobaric hypoxia.
It could be said that an explosive decompression is not a usual scenario
for glider pilots at altitude (unless you are in a pressurised cockpit
for extreme altitude flights), hence a gradual 'physiological ascent' by
turning down the oxygen ratio will simulate the insidious nature of
hypoxia during an ascent more realistically.

Decompression chambers have been associated with occurrences of the
bends, I know of one person who had the bends following a chamber run.

Any comment from AvMed types?

http://www.ingentaconnect.com/content/asma/asem/2010/00000081/00000009/a
rt00006

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