First off, you'd need to tell us what OS you're using, as the result depends on 
how you launch Avogadro.

Avogadro (and Qt) remember the last used directory for open and save dialogs.

Otherwise, it's a system-dependent default. On Linux, it's whatever was the 
current working directory. On Mac, it's either the Applications directory or 
your home folder. I believe it's similar on Windows.

Hope that helps,
-Geoff
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