----- Original Message ----- From: <[EMAIL PROTECTED]> To: <[EMAIL PROTECTED]> Sent: 02 Nopember 2000 9:13 Subject: [diskusi-autis] A Look at Vaccinations and Autism Theories > ---- Forwarded by HANNY PRASETYA/FIRMENICH on 11/02/2000 08:52 > ---- > FEAT <[EMAIL PROTECTED]> on 10/31/2000 08:33:54 > To: [EMAIL PROTECTED] > cc: (bcc: HANNY PRASETYA/FIRMENICH) > Subject: A Look at Vaccinations and Autism Theories > > FEAT DAILY NEWSLETTER Sacramento, California http://www.feat.org > "Healing Autism: No Finer a Cause on the Planet" > ______________________________________________________ > October 30, 2000 > > A Look at Vaccinations and Autism Theories > > [This is part of series of summaries of Theories of Autism written > and maintained by Lewis Mehl-Madrona, M.D., Ph.D., Medical Director of The > Center for Complementary Medicine. Email [EMAIL PROTECTED] Other > theory of autism summaries are also available at the website below. > References have been deleted but are available at the website. This > material contains technical language.] > http://www.healing-arts.org/children/ > > Dr. Andrew Wakefield, a Gastroenterologist at the Royal Free Hospital > in London, England, discovered a possible connection between autism and > viral infection associated with the MMR vaccination. The damage from autism > is thought to be provoked by the an allergic type reaction initiated by the > body > > To unsubscribe from this group, send an email to: > [EMAIL PROTECTED] > ---------------------------------------------------------------------------- ---- Æs reaction to the vaccine. This auto-immine response could also affect DPP-IV, reducing its levels, thereby connecting vaccines to the opioid theory of autism. For more information, please see The Mechanism of Encephalitic Damage from Vaccines by Val Valerian. Myelination is an essential part of human brain development. Nerves can only conduct pulses of energy efficiently if it is covered with myelin. Like insulation on an electric wire, the fatty coating of myelin helps keep the pulses confined and maintains the integrity of the electrical signal so that it has a high signal-to-noise ratio. When the insulation on a wire is damaged or destroyed, the flow of electrical current may be interrupted and a short-circuit occurs. See Colorado Health Net's MS Definitions, Facts, and Statistics for more information. Oligodendrocyte cells give white matter its color by manufacturing myelin. If myelin falls into disrepair, nerve axons cease to function, even though they themselves aren't damaged. Protecting oligodendrocytes after brain or spinal cord injury might keep nerve cells intact." See Washington University in St. Louis School of Medicine's article on new findings on nervous system damage for more information. At birth, relatively few pathways have myelin insulation. Myelination in the human brain continues from before birth until at least 20 years of age. Up until the age of 10 or so, vast areas of the cortex are not yet myelinated, and up to the age of 20, large areas of the frontal lobes are not yet myelinated 21. Myelination begins in the developmentally oldest parts of the brain, like the brain stem, moving to the areas of the nervous system that have developed more recently, like the prefrontal lobe and cortex. Myelin spreads throughout the nervous system in stages which vary slightly in each individual. Impairment of myelination can alter neural communication without necessarily causing severe CNS damage. The prefrontal portions of the cerebrum have a profound influence on human behavior. If an individual is injected with vaccines, most of which have adjuvants like mercury and aluminum compounds, as well as foreign proteins (some from other species in which the vaccines were grown) and biological organisms, unprotected nerves may be impacted. The argument for a role of vaccines in the development of autistic disorders hinges on these biological effects upon nerves, damaging them in a way that influences behavior and learning patterns. The history of studies on vaccines began in 1922 when a smallpox vaccination program caused an outbreak of encephalitis, with a secondary result of Guillain-Barre Syndrome, an ascending paralysis ending in death. The polio virus produces a breakdown of the myelin shealth, called poliomyelitis, which results in paralysis. Encephalitis, whether caused through disease or as a result of vaccination, can cause demyelination of the nerves. For more information, see again The Mechanism of Encephalitic Damage from Vaccines. "In regions in which there is no organized vaccination of the population, general paralysis is rare. It is impossible to deny a connection between vaccination and the encephalitis which follows it. 23" In 1935, Thomas Rivers discovered "experimental allergic encephalomyelitis," or (EAE). Until then, it was assumed that encephalitis was caused by a viral or bacterial infection of the nervous system. Rivers was able to produce brain inflammation in laboratory monkeys by injecting them repeatedly with extracts of sterile normal rabbit brain and spinal cord material, which made it apparent that encephalitis was an allergic reaction. EAE can explain the association of allergies and autoimmune states with encephalitis. In 1947, Isaac Karlin suggested that stuttering was caused by "delay in the myelinization of the cortical areas in the brain concerned with speech." In 1988, research by Dietrich and others using MRI imaging of the brains of infants and children from four days old to 36 months of age have found that those who were developmentally delayed had immature patterns of myelination. In 1953 it was realized that some children's diseases, measles in particular, showed an increased propensity to attack the central nervous system. This indicated a growing allergic reaction in the population to both the diseases and the vaccinations for the diseases. In 1978, British researcher, Roger Bannister, observed that the demyelinating diseases were getting more serious "because of some abnormal process of sensitization of the nervous system." Some investigators believe that this increased sensitization of the population is being enhanced by vaccination programs. DPT and Brain Damage: In 1948, Randolph Byers and Frederick Moll of Harvard Medical School and the Federal Drug Administration carried out tests on DPT vaccines at Children's Hospital in Boston and concluded that severe neurological problems could follow the administration of DPT vaccines. The results of the tests were published in Pediatrics. In 1976, Dr. Charles Manclark, an FDA scientist, remarked that "the DPT vaccine had one of the worst failure rates of any product submitted to the Division of Biologics for testing." According to the testimony of the Assistant Secretary of Health, Edward Grant, Jr., before a U.S. Senate Committee on May 3rd, 1985, every year, 35,000 children suffer neurological damage related to the DTP vaccine. See "Vaccinations", by Alex Logia, for more information. In 1992, the Institute of Medicine concluded that "the evidence is consistent with a causal relation between DPT vaccine and acute encephalopathy, defined in the studies reviewed as encephalopathy, encephalitis, or encephalomyelitis, and the evidence indicates a causal relation between DPT vaccine and anaphylaxis, between the pertussis component of DPT vaccine and protracted, inconsolable crying." For more information, see the Leading Edge Master Analysis of the Vaccination Paradigm. Like the material used to produce experimental allergic encephalitis, vaccines contain substances which qualify as "adjuvants." These substances initiate reactionary antibody formation. Common adjuvants used in vaccines are aluminum hydroxide and aluminum potassium sulfate. In the body, formalin coating around the injected material dissolves, releasing all bacterial and viral particles from animal culture sources. Substances such as thimerosal [mercury] and these adjuvant chemicals irritate body tissues and increase the action of accompanying bacteria and viruses, as well as the reaction of the immune system to the foreign protein antigens, potentially damaging neurological membranes where the myelin sheath has only partially protected the nervous system. This can result in mild to severe neurological damage, leading to learning disabilities and other nervous system disorders, or death, especially upon subsequent injections, since body has already been sensitized, promoting allergic reactions of increasingly severe nature. For more information, see again the Leading Edge Master Analysis of the Vaccination Paradigm. Dr. Charles M Poser has drawn the link between the vaccines and demyelination: "Almost any... vaccine can lead to a non infectious inflammatory reaction involving the nervous system 24. The common denominator consists of a vasculopathy that is often... associated with demyelination." For more information, see the Society For The Autistically Handicapped (S.F.T.A.H.)'s Vaccines: Fact Sheet. Jonas Salk, the developer of the vaccine, wrote in 1975, "Live virus vaccines against influenza or poliomyelitis may in each instance produce the disease it intended to prevent . . . . the live virus against measles and mumps may produce such side effects as encephalitis 25. " Post-vaccinal pathology of the central nervous system (CNS) is a topic deserving further investigation (An Italian Study Finding Biochemical Markers of Vaccine Damage, © 1996, Harris L. Coulter, Ph.D.). Observation of 30 patients of Italian nationality, observed between April, 1994, and October, 1995, showed that clinical signs of CNS pathology, along with associated dermatitis, food allergies, constipation, and leaking from the anus, emerged concomitantly or immediately after vaccination with the Salk or Sabin polio vaccine, DT, measles, DPT, anti-tuberculosis, or Hepatitis-B vaccines 26. These 30 patients from various regions of Italy, all presented with a clinical history of convulsions concomitant with, or immediately after, vaccinations. Patients whose clinical history was not referable to a vaccination were excluded from the study. Accepted patients received tissue typing for HLA (A, B, C) and HLA DR-DQ. Various immune functions: were also studied, including lymphocyte subpopulations, serum immunoglobulin content, and presence of antibodies to specific viruses (CMV, EBV, HSV-1 and HSV-2, VZV). Patients had earlier been diagnosed with epilepsy, myoclonic epilepsy, evoving epilepsy, epileptigenic encephalopathy, autism, West Syndrome, and Angelman's Syndrome. All the patients had presented with the first symptoms shortly after receiving a vaccination. The first symptoms were convulsions, high fever, or diarrhea immediately following vaccination. The parents had told their physicians about this; then, after taking EEGs and visiting neuropsychiatric specialists or pediatricians without conclusion, the physicians had administered the recall shots of the vaccines leading to stabilization of the condition with progressive clinical deterioration. Children were 3 to 9 months old. All patients were studied for the presence of metabolic diseases with negative results; then chromosomal mapping was done, also with negative results; encephalic TAC and RMN were performed at first appearance of the symptomatology, also with negative results. The EEG performed at first appearance of the symptomatology gave a negative result in 92% of the patients. Serologic investigations for herpetic virus (IgG and IgM) were positive in all for IgG and negative for all for IgM, leading to an estimate of seropositivity (IgG) for Epstein-Barr virus of 73.8%; for cytomegalovirus, of 71.4%; for Herpes Simplex virus, of 47.6%; and for Varicella-Zoster Virus of 21.4%. In all the patients they observed diminished sideremia and a deficit of IgA and IgG with a slight increase of SGOT and SGPT. None of the patients had maternally transmitted viral encephalopathy, and in all the patients the vegetative and relational life was quite normal prior to administration of the first dose of vaccine. Again, see An Italian Study Finding Biochemical Markers of Vaccine Damage, for more information. Take Some Mystery out of Autism >> SUBSCRIBE << Emailed to you Daily no cost: http://www.feat.org/FEATNews MMR Vaccine and Autism: Elevated Rubeola Titers in Autistic Children and MMR vaccine: T. Zecca , et al. at the New Jersey Medical School's Children's Hospital of New Jersey in Newark compared rubeola virus in autistic and normal children. Among 16 children diagnosed with autism followed in their clinical practice, they found a 3-fold increase in rubeola titers over expected normal range. A Wilcoxon Kruskal Wallas test comparing 13 rubeola titers from normal children revealed a statistically significant p-value of 0.005. Subjectively, parents have stated that their children's developmental milestones deteriorated following MMR vaccination. Neurological sequelae following MMR are widely reported. The authors suggested that elevated titers of anti-measles antibodies in autistic children could signify a chronic activation of the immune system against this neurotropic virus, which may play a role in the pathogenic sequences of events leading to autism. They emphasized the need for further studies. Vaccination and the Risk for Autism: Do vaccines contribute to autism? A February 28, 1998, report in The Lancet suggested an association among inflammatory bowel disease, autism, and measles-mumps-rubella (MMR) vaccine based on 12 cases. Dozens of heart-rending anecdotal accounts link permanent neurologic disability or death to vaccine use. One of the leading sites in the anti-immunization field is the National Vaccine Information Centre (NVIC). Some information about the risks and side effects of vaccines on the NVIC site is accurate in spite of its overwhelming emphasis on the risks of vaccination. Nevertheless, as the site states, "Vaccination is a medical procedure which carries a risk of injury or death. As a parent, it is your responsibility to become educated about the benefits and risks of vaccines in order to make the most informed, responsible vaccination decisions." A similar statement can be made about any medical procedure. There area also possible, but unproven links between MMR vaccine and juvenile diabetes, multiple vaccines and autism, and OPV and Gulf War syndrome. Time and further research will tell if these proposed relationships are real. In the Lancet report, Dr. Wakefield and team from Royal Free Hospital and School of Medicine in London reported a case series of 12 children, referred to their pediatric gastroenterology clinic with a diagnosis of pervasive developmental disorder and intestinal symptoms. These children had lost acquired skills, including communication, after a period of apparent normality. Among eight of the children, the onset of behavioral problems had been linked, either by the parents or the child's physician, with MMR vaccination. Five had an early adverse reaction to immunization (rash, fever, delirium, and seizures in 3). The average interval from exposure to first behavioral symptom was 6.3 days (range 1-14). Among the remaining 4 children, one received monovalent measles vaccine at 15 months, after which his development slowed. A striking deterioration then occurred in his behavior at age 4.5 years, the day after he received an MMR vaccine. A second child received the MMR vaccine at 16 months, developing at 18 months a combination of recurrent, antibiotic resistant, otitis media, along with his first behavioral symptoms (lack of interest in siblings and lack of play). A third child received an MMR at 15 months, experienced recurrent "viral pneumonia" for the next 8 weeks, and developed behavioral symptoms 4 weeks after the MMR ( loss of speech development and deterioration in language skills). The fourth child developed self- injurious behavior 2 month after the MMR. Urinary methylmalonic - acid excretion was significantly raised in all children tested (8 of the 12). Ten of the twelve children showed lymphoid nodular hyperplasia of the terminal ileum on endoscopy. The eleventh child had prominent luteal lymph nodes and the ileum was not reached in the twelfth (who had an ulcer in the rectum along with chronic colitis). Other studies have suggested a link between autism and vaccination. H.H.Fudenberg reported that the first symptoms of autism among 15 of 20 children developed within a week of vaccination. S.Gupta commented on the striking association between MMR vaccination and the onset of behavioral symptoms in all the children he investigated for regressive autism. The MMR vaccine is all live virus. Disintegrative psychosis is recognized as a sequela of measles encephalitis. Viral encephalitis can give rise to autistic disorders, particularly when it occurs early in life. A genetic association for autism is represented by a null allele of the complement C4B gene located in the class III region of the major histocompatibility complex. The C4B-gene is also crucial for protection against viruses. Affected individuals may not handle certain viruses appropriately; even the attenuated ones used in vaccines. In an addendum to the paper, the authors noted that their sample size had increased to 40 children by Jan 28,1998, with 39 of those showing similar findings. These studies raise an important provocative point. MMR vaccine may trigger a cascade of events leading to autism in genetically susceptible children. The possibility must be further studied. Unfortunately vaccination among public health and medical practitioners has become almost sacred. Questioning the wisdom of vaccination for certain children is seen as professional heresy. Nevertheless, the possibility cannot be ignored. Could killed MMR accomplish the same task? Should measles be administered separately from mumps? We know that the combination of chicken pox and measles dramatically increases the risk for subacute sclerosing panencephalitis. Perhaps other mixed viral infections are also clinically significant. More important is the science we must use to explore this. Simply correlation analysis and comparison studies will not suffice. If autism is linked to MMR vaccine in genetically susceptible individuals, unless these individuals are selected from the larger pool, the statistical significance will cancel out. Medical research suffers from a failure to consider interactions and synergy in the disease process. Simple epidemiology will not suffice, since we are not even sure what the potential genetic defect is in autism or if autism is one syndrome or many. * * Summary Commentary: The vaccine-autism connection is very much still a big question mark. After sifting through what has been studied and reported on the subject, pro or con, the following facts do remain: The incidence of Autism has increased significantly in the last decade. There is every reason to believe that this trend will continue. No one has proved that MMR vaccine plays a role in autism. No one has proved conclusively that it does not. Serious studies by independent researchers are desperately needed, to look into all aspects of this dreadful disease. ---------------------------------------------------------------------------- ---- > ---------------------------------------------------------------------------- ---- ûLenny Schafer _____________________________________________________ Send Your United Way Contributions to FEAT Put "16106" on your Donor Card Combined Federal Program Number is "3180" Or: FEAT PO Box 255722 Sacramento CA 95865 ______________________________________________________ LETTERS to the EDITOR: | NEWS EDITOR: | NEWS SEARCH: [EMAIL PROTECTED] | [EMAIL PROTECTED] | www.feat.org/search/news.asp * JOIN News Talk LIST: [EMAIL PROTECTED] * _____________________________________________________ Editor: Lenny Schafer | Eastern Editor: | News Wire: Ron Sleith [EMAIL PROTECTED] | Catherine Johnson PhD | News: Kay Stammers >>>> 2.5 Mbps InternetShop >> InternetZone << Margonda Raya 340 <<<< >> Kirim bunga ke-20 kota di Indonesia? 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