Hi all,

We have released BASE 2.7.2. The release includes important bug fixes
in the LOWESS plug-in shipped as a part of the BASE package. Some
other improvement are also included in the release.

It is highly recommended at all BASE installations where LOWESS is
used as a part of their analysis in BASE are upgraded to this
release. More details on the LOWESS problem is given below.

Note, we have not found any problems with the BASE1 lowess
implementation and analysis made with BASE1 lowess in BASE1 or BASE2
are still valid.

More information about the changes in 2.7.2:

Download from:

We regret any inconvenience that the LOWESS bug may have caused,

The Lund BASE team

Text copied from the installation/upgrade chapter of the BASE

Bug in the LOWESS plug-in affecting BASE version 2.0 -- 2.7.1

This release fixes a serious bug in the LOWESS plug-in shipped as a
part of the BASE package. The bug is found in all BASE versions
between 2.0 and 2.7.1, and has caused incorrect normalization values
to be calculated. All data that has been normalized with the BASE2
LOWESS plug-in prior to BASE 2.7.2 should be considered invalid and
needs to be re-normalized with the fixed version. Downstream analysis
steps that has used the incorrectly normalized data also needs to be
redone. For more information about the bug see

BASE 2.7.2 includes a utility for finding all experiments/bioassay
sets that includes data normalized with the LOWESS plug-in. An
administrator can use this utility to extract a list of all
experiments/bioassay sets that needs to be fixed. The utility can also
tag the name of the found experiments/bioassay sets with FIX LOWESS to
make it easier to find data that needs to be fixed.
The utility can't see any difference between data normalized with the
old version and the fixed version. It will simply report all data that
has been normalized with the LOWESS plug-in. Only use the utility a
single time right after the upgrade to BASE 2.7.2.
The utility is a command line program that should be executed on the
BASE application (web) server.
cd <base-dir>/bin
./onetimefix.sh lowess_warn -u <login> -p <password> -f
We recommend running the utility as the root user. The -f option is
optional. If it is included the found experiments/bioassay sets are
tagged with FIX LOWESS, otherwise only a list with the information is

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