Hi Ron, > I believe the slow execution may be due to a combinatorial issue: the cross > product of 280,000 clinical trials and ~10,000 drugs in DrugBank (not > counting synonyms).
Yes, this sounds like a pretty expensive operation. Having maps (XQuery, Java) will be much faster indeed. As Gerrit suggested, and if you will run your query more than once, it would definitely be another interesting option to build an auxiliary, custom "index database" that allows you to do exact searches (this database may still have references to your original data sets). Since version 9 of BaseX, volatile hash maps will be created for looped string comparisons. See the following example: let $values1 := (1 to 500000) ! string() let $values2 := (500001 to 1000000) ! string() return $values1[. = $values2] Algorithmically, 500'000 * 500'000 string comparisons will need to be performed, resulting in a total of 250 billion operations (and no results). The runtime is much faster as you might expect (and, as far as I can judge, much faster than in any other XQuery processor). Best, Christian