>> I also use many tricks to reuse computations across various proteins.
>> For example, the matrix for protein "ABCDE", is identical, at first

Have you gotten any blast source code? This would be a good thing to
start with for a number of reasons. But, don't assume that a given 
implementation
is either well optimized of naive. Sure, they could have
code like

get_parameters();
metric=do_expensive_metric_thing();
if ( metric
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