No, that inference is not generally possible. Only if the proteins are very(!) closely related. Google "interologs" for background on the limits of annotation transfer for interacting proteins.
B. On 15-Sep-07, at 6:57 PM, Mahmoud Elhefnawi wrote: > Dear all, > > I was wandering if BLOCKS database homology hits with significant e > values habe been correlated before to infer protein protein > interactions? > > i.e" if protein A interacts with protein B, and protein C has a > significant match with protein B, then protein C also interacts > with protein A??? > > Best, > Mahmoud > _______________________________________________ > BBB mailing list > [email protected] > http://www.bioinformatics.org/mailman/listinfo/bbb _______________________________________________ BBB mailing list [email protected] http://www.bioinformatics.org/mailman/listinfo/bbb
