Unless I'm mistaken, Pankaj had asked for sources on up and down-regulated proteins, not genes. I frequently make use of the information in the Geo datasets to target genes encoding proteins whose expression might be changed under a set of experimental conditions. However, it is important to keep in mind there is often no correlation between changes in gene expression (as presented in such microarray datasets) and protein levels. As long as these caveats are kept in mind, such datasets represent a good jumping off point for identifying proteins of potential relevance to your particular experiment. John
John G. Hoey, Ph.D. Sent from my iPhone On Mar 14, 2010, at 10:51, Maximilian Haussler <[email protected]> wrote: I assume that you either have to read papers for this (google: microarray hypoxia upregulated genes) and then get their supplemental data or do bit of digging in NCBI GEO. Here is a hypoxia dataset in geo that I've found by searching geo for hypoxia: http://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE3188 I think nextbio has already processed the data in the way that you need but it's a company and I don't know which part you can use for free is you're a researcher: http://www.nextbio.com/b/search/disc.nb?q=hypoxic#cat=Genes good luck Max -- Maximilian Haussler Tel: +447542993736 +447574054746 http://www.ls.manchester.ac.uk/people/profile/index.asp?id=4774 On Tue, Mar 9, 2010 at 6:34 AM, Pankaj Khurana <[email protected]> wrote: Hi all, I would like to get a list of all proteins that are upregulated/downregulated during hypoxia. How can I get a list of these proteins? Thanking all in advance Dr. Pankaj Khurana India _______________________________________________ BBB mailing list [email protected] http://www.bioinformatics.org/mailman/listinfo/bbb _______________________________________________ BBB mailing list [email protected] http://www.bioinformatics.org/mailman/listinfo/bbb _______________________________________________ BBB mailing list [email protected] http://www.bioinformatics.org/mailman/listinfo/bbb
