Andrew D. Fant wrote:
The 64-bit motivation is mostly about providing adequate memory for multiple users running gui applications.
How big are the apps? Assuming they only use one or two gigs of memory a piece, you should be able to have a 32-bit machine with lots of RAM. Or even an opteron with lots of RAM with a 32-bit OS on it. That would save you from having to worry about any 32 vs 64 bit issues.
With that said, having a 64-bit head node and 32-bit compute nodes isn't difficult. Like Reuti said, just make sure you're careful about where you compile your code.
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