Dear Anita, Homology modeling involves taking a known sequence with an unknown structure and mapping it against a known structure of one or several similar (homologous) proteins. It would be expected that two proteins of similar origin and function would have reasonable structural similarity. Therefore it is possible to use the known structure as a template for modeling the structure of the unknown structure.
All homology modeling approaches consists of three steps 1. Finding homologus PDB files. 2. Creation of the alignment, using single or multiple sequence alignments. (if more than one known is involved, sometimes the knowns are aligned together, then the unknown sequence aligned with the group; this helps ensure better domain conservation) Analysis of alignments; gap deletions and additions; secondary structure weighting 3. Structure calculation and model refinement. You can use web server SWISS MODELLER for homology modeling. Good Luck Regards, Sunandan -- Dear Member, http://www.cbclickbank.com/bioinformatics/company.htm List of the biotech company and address. Invite your friends, click the link and login, <a href="http://groups.google.co.in/group/biofriend_india/members_invite"/>Click Here to Invite Friends</a> OR http://groups.google.co.in/group/biofriend_india/members_invite Support Us to Help Others Biofriend India Team ========================================= " No email " visit http://www.cbclickbank.com/bioinformatics/giudence.htm
