*biointelligence                2nd  feb 2010*



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*ADAN: A Database for Prediction of Protein Protein Interactions*


In the last post we had given an introductions to MIPS (Mammalian Prtein
Protein Interaction database). Most of the structures and functions of
proteome globular domains are yet unknown. We can use high-resolution
structures from different modular domains in combination with automatic
protein design algorithms to predict genome-wide potential interactions of a
protein. Todays post introduces a database whcih helps in prediction of such
protein interactions.

*                                  ADAN database* is a collection of
different modular protein domains (SH2, SH3, PDZ, WW, etc.). It contains
3505 entries with extensive structural and functional information available,
manually integrated, curated and annotated with cross-references to other
databases, biochemical and thermodynamical data, simplified coordinate
files, sequence files and alignments. Prediadan, a subset of ADAN database,
offers position-specific scoring matrices for protein?protein interactions,
calculated by FoldX, and predictions of optimum ligands and putative binding
partners. Users can also scan a query sequence against selected matrices, or
improve a ligand?domain interaction.


*The ADAN Database can be accessed from here:http://adan-embl.ibmc.umh.es/*

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*Regards,
Team Biointelligence
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*Biointelligence*

*Getting started with biosciences*

*Website: www.biointelligence.in*

*Email: [email protected]
Tel: +91-731-425-7930*


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