Cell Wall Synthesis Targets of Mycobacterium tuberculosis A review for osdd community
*Reshmi.D**@, **U.C.Abdul jalee...@**, Prasad M Alex#, Prof Geetha Parameswaran** * *...@*cheminformatics division. Malabar Christian Calicut #Marthoma College Chungathra, * **University of Calicut Abstract Mycobacterium tuberculosis being the main disease causing pathogen of Tuberculosis which has become a dreadful disease worldwide was studied and the bacteria’s rapid rise in multidrug resistant property towards antibiotics was pointed out. Mycobacterium tuberculosis cell wall was observed to be having many unique characteristics which can be used to study in more depth to understand new potential Tuberculosis drug targets. The most promising enzymes and genes coding particular enzymes were studied which can be used as a potential drug target for Tuberculosis. Keywords Mycobacterium tuberculosis, Potential drug target, Multidrug resistant Introduction Tuberculosis (TB) one of the most dreaded infectious killers emerging as an infectious diseases affecting the entire populations.[1,2] And in recent years as a consequence of prolonged therapeutic exposure to drugs, a troubling rise in the emergence of multi-drug resistant and extreme drug resistant (XDR) strains.[2] Today more than five decades after the advent of the first anti-TB drugs, the World Health Organization estimates that the one third of the global population (more than two billion people) is infected with the pathogen, *Mycobacterium tuberculosis* ( *Mtb*). . India, China, Indonesia, Nigeria and South Africa rank first to fifth in terms of the total number of incident cases. It is quite alarming that India ranks first in the number of incidences. Developing antituberculosis drug is a national requirement. *Open source drug discovery * is becoming more popular among the young researchers; the new volatile targets are being identified. Better leads for the discovery are under consideration. Consolidation of major drug target of antituberclosis research results in 4 classes: Cell wall synthesis, Electron transport, Nucleic acid synthesis, Replication and Transcription.Devolpement of drugs by considering above target may produce friutfull results. Understanding and analyzing the target pathways will definitely help the future research in this area. ---------------------------- read more http://sysborg2.osdd.net/web/drjaleel/blogs -- Dr U.C.A.Jaleel. Asst Professor in cheminformatics Cheminformatics Division( UGC) Malabar Christian College Calicut University -- http://www.cbclickbank.com/bioinformatics/company.htm List of the biotech company and address. ------------------------------------------------------------------------------------------ Biofriend Forum http://www.biofriend.info/ ============================================= Meet Biofriend India Team Manager at Linkedin http://in.linkedin.com/in/satishchauk
