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ORGANIZER;CN="Zhang, Yongqing (NIH/NIA/IRP) [E]";SENT-BY="MAILTO:sdavis2@mail.
 nih.gov":MAILTO:[email protected]
ATTENDEE;ROLE=REQ-PARTICIPANT;PARTSTAT=NEEDS-ACTION;RSVP=TRUE;CN=List BIOIN
 FO-GENERAL-NCI:MAILTO:[email protected]
DESCRIPTION;LANGUAGE=en-US:\n\nFrom: "Zhang\, Yongqing (NIH/NIA/IRP) [E]" <
 [email protected]>\nReply-To: "Zhang\, Yongqing (NIH/NIA/IRP) [E]" <y
 [email protected]>\nDate: Thursday\, March 28\, 2019 at 11:52 AM\nTo: 
 <[email protected]>\nSubject: Biowulf 20th anniversary sem
 inar series: Ryan Dale (NICHD)\n\n\n\n____________________________________
 _________\nFrom: Susan Chacko <[email protected]<mailto:[email protected]
 V>>\nSent: Thursday\, March 28\, 2019 9:19 AM\nTo: List BIOINFORMATICS-SIG
 -L <[email protected]<mailto:[email protected]
 .GOV>>\nSubject: Biowulf 20th anniversary seminar series: Ryan Dale (NICHD
 )\n\n\n\n\nThe Biowulf 20th Anniversary Seminar Series continues with:\n\n
 Integrative analyses of gene regulation via long-range chromatin interacti
 ons\n\n\n[cid:[email protected]]Ryan Dale (Scientific Informa
 tion Officer and Bioinformatics Core Lead\, NICHD)\nTuesday\, 9 April 2019
 \n11 am - noon\nBldg 50\, Rm 1227\n\nThis talk will be videocast at https:
 //videocast.nih.gov/summary.asp?live=31795\n\nAbstract:\n\nThroughout deve
 lopment\, gene expression is regulated in part by interactions between gen
 e promoters and distal enhancers that can be tens or hundreds of kilobases
  away. Our recent work has identified novel mechanisms of such long-range 
 regulation in fly and mouse models. In Drosophila\, Argonaute2 is canonica
 lly part of the post-transcriptional siRNA silencing machinery. We show it
  also plays a role in transcription regulation via chromatin topology and 
 RNA PolII phosphorylation though integrative analysis of RNA-seq\, ChIP-se
 q\, ChRIP-seq\, and 4C-seq assays. In mouse\, the erythroid transcription 
 factor LDB1 is known to homodimerize to facilitate enhancer-promoter inter
 actions\, but by combining new data with published work we show that it ca
 n also interact with the architectural protein CTCF to promote the erythro
 id gene program in mouse. The software infrastructure that makes such inte
 grative analyses possible -- and reproducible -- will also be highlighted.
 \n\n________________________________\n\nTo unsubscribe from the BIOINFORMA
 TICS-SIG-L list\, click the following link:\nhttp://list.nih.gov/cgi-bin/w
 a.exe?SUBED1=BIOINFORMATICS-SIG-L&A=1\n\n________________________________\
 n\nTo unsubscribe from the BIOINFORMATICS-SIG-L list\, click the following
  link:\nhttp://list.nih.gov/cgi-bin/wa.exe?SUBED1=BIOINFORMATICS-SIG-L&A=1
 \n
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SUMMARY;LANGUAGE=en-US:FW: Biowulf 20th anniversary seminar series: Ryan Da
 le (NICHD)
DTSTART;TZID=Eastern Standard Time:20190409T110000
DTEND;TZID=Eastern Standard Time:20190409T123000
CLASS:PUBLIC
PRIORITY:5
DTSTAMP:20190328T153022Z
TRANSP:OPAQUE
STATUS:CONFIRMED
SEQUENCE:0
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