Hi,

It depends what you want to do and how you intend to build up the user
 interface.

E.g. we are using BioJava on the server side to calculate structure
alignments. For the html front end the Jmol applet is being used for
visualization:

http://betastaging.rcsb.org/pdb/workbench/showPrecalcAlignment.do?action=pw_ce_cp&pdb1=1VHR&chain1=A&pdb2=2IHB&chain2=A


Andreas
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