Substituting blood transfusions
New research to substitute blood in transfusions
Do you have a rare blood group or are you concerned about
contracting a disease such as HIV from a blood transfusion? The
first ever European Blood Substitutes project
('EuroBloodSubstitutes') is designing molecules which will be able
to replace the need for blood during transfusions in the future.
Researchers are modifying the genes of the oxygen-carrying part of
the blood (haemoglobin) and using cell factories to mass produce
artificial molecules which will be able to oxygenate the body's
cells as efficiently, but without the possibility of contamination
with disease.
Dr Ken Lowe (University of Nottingham, UK) who is coordinating the
project says "We are using genomics to modify the haemoglobin as
well as looking at ways to attach it to large molecules so that it
stays in the body longer during transfusions. We are aiming to find
the optimum molecules for oxygen-binding and transport as well as
the best culture conditions for mass producing it for the future."
Dr Lowe will be reporting his results at the Society for
Experimental Biology Annual Meeting in Barcelona on Tuesday 14th
July [session E3.2].
This initiative is set to revolutionise blood transfusions which
will become largely safe especially in emerging countries such as
Eastern Europe and Africa where there are still relatively high
risks of contamination.
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