Fedora is a very good distribution. I personally recommend the MATE-Compiz spin.
https://spins.fedoraproject.org/en/mate-compiz
It can certainly be installed easily, comes with the VirtualBox guest editions
and other similar helpers for running in virtual environments, and also ships
with orca out of the box. Eventually it will be better to run any distribution
on bare metal and run any other operating system you want in the virtual
environment, but for either use case, Fedora-MATE-Compiz is very comprehensive,
solid and stable.
~Kyle
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