This manual describes the operation and theory of the PC-CARES (Personal 
Computer-Ceramic Analysis and Reliability Evaluation of Structures) 
computer program for the IBM PC and compatibles running PC-DOS/MS-DOR OR 
IBM/MS-OS/2 (version 1.1 or higher) operating systems. The primary purpose 
of this code is to estimate Weibull material strength parameters, the 
Batdorf crack density coefficient, and other related statistical 
quantities. Included in the manual is the description of the calculation of 
shape and scale parameters of the two-parameter Weibull distribution using 
the least-squares analysis and maximum likelihood methods for volume- and 
surface-flaw-induced fracture in ceramics with complete and censored 
samples. The methods for detecting outliers and for calculating the 
Kolmogorov-Smirnov and the Anderson-Darling goodness-of-fit statistics and 
90 percent confidence bands about the Weibull line, as well as the 
techniques for calculating the Batdorf flaw-density constants are also 
described.

loads may be either tensile or compressive. Several standardized aircraft 
flight-load histories, such as TWIST, Mini-TWIST, FALSTAFF, Inverted 
FALSTAFF, Felix and Gaussian, are included as options. FASTRAN II also 
includes two other methods that will help the user input spectrum load 
histories. The two methods are: (1) a list of stress points, and (2) a 
flight-by-flight history of stress points. Examples are provided in the 
user manual. Developed as a research program, FASTRAN II has successfully 
predicted crack growth in many metallic materials under various aircraft 
spectrum loading. A computer program DKEFF which is a part of the FASTRAN 
II package was also developed to analyze crack growth rate data from 
laboratory specimens to obtain the effective stress-intensity factor 
against crack growth rate relations used in FASTRAN II. FASTRAN II is 
written in standard FORTRAN 77. It has been successfully compiled and 
implemented on Sun4 series computers running SunOS and on IBM PC 
compatibles running MS-DOS using the Lahey F77L FORTRAN compiler. Sample 
input and output data are included with the FASTRAN II package. The UNIX 
version requires 660K of RAM for execution. The standard distribution 
medium for the UNIX version (LAR-14865) is a .25 inch streaming magnetic 
tape cartridge in UNIX tar format. It is also available on a 3.5 inch 
diskette in UNIX tar format. The standard distribution medium for the 
MS-DOS version (LAR-14944) is a 5.25 inch 360K MS-DOS format diskette. The 
contents of the diskette are compressed using the PKWARE archiving tools. 
The utility to unarchive the files, PKUNZIP.EXE, is included. The program 
was developed in 1984 and revised in 1992. Sun4 and SunOS are trademarks of 
Sun Microsystems, Inc. IBM PC is a trademark of International Business 
Machines Corp. MS-DOS is a trademark of Microsoft, Inc. F77L is a trademark 
of the Lahey Computer Systems, Inc. UNIX is a registered trademark of AT&T 
Bell Laboratories. PKWARE and PKUNZIP are trademarks of PKWare
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To evaluate the status of community pharmacies, their staff, and practices 
toward dispensing antibiotics. Cross-sectional, prospective. Community 
pharmacies in two districts of central Nepal, from March 2016 to May 2016. 
A systematic random sampling approach was adopted to sample 161 community 
pharmacies. Data on the registration status of pharmacies, qualification or 
training of dispensing staff, and the practice of dispensing antibiotics 
were collected using a pre-tested questionnaire. Face to face interviews 
were carried out by a previously trained interviewer. Data were analyzed 
for descriptive and inferential statistics using IBM SPSS Statistics 21. 
Among 161 community pharmacies, 25% were not registered and most of them 
were located in rural areas. It was typical (66.5%) to dispense antibiotics 
without prescription and most (91.4%) of the staffs involved in dispensing 
were non-pharmacists. Furthermore, the study revealed common practices of 
replacing one brand of antibiotic with other brands (66%), dispensing 
incomplete courses of antibiotics (73%), and not giving any advice 
regarding antibiotic use (39%) or completion of a full course of therapy 
(80%). There were significant (p < 0.001) relationships between the 
location of pharmacies (rural vs urban) and the qualifications of the 
pharmacy staff. Dispensing antibiotics without prescription and by 
non-pharmacists are common in this region. The study also found several 
issues regarding the irrational use of antibiotics. Thus, there is an 
urgent need to address these issues and promote the informed use of 
antibiotics.
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