--- Sonja wrote:
<huge snip> 
> Does population wide vacination make viruses that
> have been around for ages more virulent?

Off the top of my head, no, I am not aware of that
being a significant problem, although theoretically it
_could_ select for a hardier type.  Some viruses, like
influenza A, are so intrinsically variable that
vaccines could only select a type out for a year or
two (which is one of the reasons I gather that making
a vaccine for HIV is so difficult - it has inherent
mutability in the components (such as outer coating)
that one uses).

I think that _vaccination_ pressure is different from
_antimicrobial_ (or virucidal) pressure when it comes
to selecting out hardier or more virulent bugs,
because the former is _indirectly_ improving target
host defenses, while the latter is acting _directly
on_ the pathogen in question.

But I'm going to have to look into that to be
certain... Ben?  What do you think?

Debbi

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