We support running GuixSD on top of btrfs, and the prevailing wisdom is to mark databases (sqlite, postgresql, etc.) as 'chattr +C', that is, as not copy-on-write. It is honored under ext4, but it shouldn't cause any changes.
-- Efraim Flashner <[email protected]> אפרים פלשנר GPG key = A28B F40C 3E55 1372 662D 14F7 41AA E7DC CA3D 8351 Confidentiality cannot be guaranteed on emails sent or received unencrypted
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