Hi Clayton,
I don't know if this is an option for you - use an MPRAGE sequence instead of a FLASH, you'll get much less vasculature in your image volume and better grey/white contrast. Re tweaking Caret, I'd suggest trying different peaks, have a look at Donna's peak tweaking tips on the caret web site. I usually have to skew my choice a bit to the left.
Cheers,
Johannes

Clayton Curtis schrieb:
I've recently been using Caret to segment brains and have been looking for ways to reduce the amount of time needed to hand-clean the topological errors. I've found that using FSL's susan_smooth twice on an image and correcting for inhomogeneity of signal intensity REALLY helps tremendously. However, I'm still having to do quite a bit of hand-cleaning almost entirely due to high intensity (bright white) voxels of the vasculature confusing the g/w matter algorithm. I'm writing to ask if anyone has a good solution to this problem. I've tried to null voxels above a certain cutoff but that appears to grab too many voxels in true white matter.
Thanks for any suggestions!

*/cc*
*
*
*Clayton E. Curtis, Ph.D.*
*Psychology & Neural Science*
*New York University*
*6 Washington Place, Room 859*
*New York, NY 10003*
*Office - 212.998.3730*
*Lab - 212.998.8347*
*Fax - 212.995.4562*
*http://www.psych.nyu.edu/curtislab*



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