So to be just totally clear: what I actually want is this:

If you look at the figures I attached you'll see two main components: the
gm and wm, characterised by signal intensity. We can use that to make a
line at the wm/gm and another at pial and we obtain two surfaces enclosing
the gm.

But in my figures, in this animal, note that there is a both a clear
boundary and clear intensity change within the white matter. Just like
wm/gm.

So I want to make a surface that treats this inner boundary as if it were a
gm/wm boundary. In order to characterise the properties of wm in those
regions.

Thinking about it, the best move may be to cut out the gm, and treat the
outer shell as if it's gm. Freesurfer might then compute what I want .
That's better than linear contraction. But harder. Yet More staring at 3
million voxels...but that's ok.

Unless there's a surfeit trick/hack or something....surfeit made a marmoset
mid thickness that was plausible. That's impressive. With freesurfer I have
to make a fake volume by hand.

Marmosets are the only primate that is germ line transgenic. So you can
make a colony of marmosets with parkinsonism in principle. It has a small
brain so you can scan at high res. It is small and easy to house compared
to rhesus. It has twins twice a year. It's adult in 2 years.

It's the model animal of the future...ask the folks in Japan :).

Thanks

 Colin.

On Monday, 27 August 2012, wrote:

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