Adult Stem Cells May Help Childhood Motor Neuron Disease

<http://www.frcblog.com/2008/09/adult_stem_cells_may_help_chil.html>http://www.frcblog.com/2008/09/adult_stem_cells_may_help_chil.html
 


Researchers at the University of Milan 
<http://jci.org/articles/view/35432>have published results indicating 
that 
<http://www.eurekalert.org/pub_releases/2008-09/joci-sct082808.php>adult 
neural stem cells might be used as a treatment for spinal muscular 
atrophy. This motor neuron disease is the second most common genetic 
disorder leading to death in childhood. Using a mouse model for the 
disease, the scientists injected neural stem cells into the spinal 
cords of animals. They found that treated mice showed improved 
muscular function and increased lifespan compared to untreated 
controls. While some of the transplanted cells developed into motor 
neurons, the major effect of the injected cells seems to be improving 
survival and function of existing motor neurons already present in 
the mice, suggesting that the adult stem cells secrete factors to 
assist survival and regeneration.

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