<http://www.telegraph.co.uk/news/newstopics/politics/health/3270549/Worlds-most-advanced-artificial-heart-as-good-as-the-real-thing.html>World's
 
most advanced artificial heart 'as good as the real thing'



The world's most advanced artificial heart has 
been unveiled, with its inventor claiming it 
perfectly replicates the human organ.

By Henry Samuel in Paris
Last Updated: 11:06AM GMT 28 Oct 2008
French heart transplant specialist Alain Carpentier presents a

French heart transplant specialist Alain 
Carpentier presents a prototype of the world's 
first fully implantable artificial heart. Photo: AP

Professor Alain Carpentier has unveiled the 
device three decades after the world's first human heart transplant.

The French doctor has described it as the world's 
first fully implantable artificial heart and says 
it could save the lives of thousands of heart 
patients, many of whom die while waiting for a heart donation.

The revolutionary life-size mixture of animal 
tissue, titanium and missile technology is 
covered in specially treated tissue to avoid 
rejection by the body's immune system and in 
particular the formation of blood clots.

Thanks to the latest electronic sensor technology 
used in guided missiles, the heart can also 
respond instantly to changes in blood pressure 
and flow and adapt the heart beat rate accordingly.

"If you showed the electrocardiogram to a 
cardiologist he would say 'that's a human heart.' 
Well no, it isn't: it's a prosthesis," said Prof 
Carpentier, head of research on cardiac grafts 
and prostheses at Georges Pompidou hospital in Paris.

Prof Carpentier has been working in the utmost 
secrecy on the project for 15 years in 
conjunction with engineers from the Franco-German 
defence and aerospace company EADS.

While there are other rival laboratories working 
on artificial hearts in America, Japan and South 
Korea, the French say their design is superior.

In particular, Prof Carpentier used his expertise 
as a world authority in artificial heart valves 
to overcome the problem of blood clots - the main 
stumbling block in other attempts to build an 
artificial heart. He did this by using specially 
sterilised "bioprosthetic" pig cartilage and by 
replicating the exact same blood flow - or 
hemodynamics - of the human heart that reduce blood clot risks.

"The aim of this heart is to allow patients to go 
from an impossible life where they can do just a 
few steps from their bed to an armchair to a 
normal social life. They will even be able to run 
- although naturally not a marathon," he said.

Weighing around a kilo, the only external part of 
the man-made organ is its battery which has a five-hour charge life.

Prof Carpentier said the new heart was necessary 
given the chronic shortage of heart donors and 
growing heart patient waiting lists. "I couldn't 
stand seeing young, active people dying aged 40 
from massive heart attacks," he said.

Professor Peter Weissberg from the British Heart 
Foundation said "only properly conducted trials" 
would be able to establish whether this new model 
would live up to Pro Carpentier's claims.

"There is a definite need for a reliable, safe 
artificial heart because there aren't enough 
donor hearts for all who need a transplant to have one," he said.

"This is the latest of several attempts to 
engineer an artificial heart that will do the 
heart's job effectively without any dangerous side effects

"Despite their early promise in laboratory 
experiments most versions so far have been found 
not to perform as well as predicted when tried in 
patients – they either fail to do the job 
properly or, more commonly, cause debilitating 
side effects through infections or blood clots."

He added: "It will take some years to establish 
the place of this particular artificial heart in 
the management of patients with end stage heart failure."

Heart disease is among the world's biggest 
killers, claiming 17 million lives per year.

About 55 million euros (£44 million) has been 
spent creating the prototype. The groundbreaking 
organ has already been successfully implanted in 
calves although most tests have been done via computer simulation.

"The artificial heart is ready and now needs to 
be industrially made," said Prof Carpentier, who 
added that none of its parts had shown any sign of "wearing out".

Assuming French medical authorities give the 
go-ahead, it will be tested on around 20 
volunteer heart patients within the next two and a half years.

The heart will be built by Carmat, a biomedical 
subsidiary of EADS, with funding from Oseo, the 
French state bank that supports innovative 
companies, as well as from venture capitalists.

Given the materials and technology involved, it 
is estimated that each heart will cost around £120,000.


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