<http://web.israel21c.net/bin/en.jsp?enDispWho=Articles%5El2328&enPage=BlankPage&enDisplay=view&enDispWhat=object&enVersion=0&enZone=Health>Stopping
 
the pain of 
PTSD<http://web.israel21c.net/bin/en.jsp?enDispWho=Articles%5El2328&enPage=BlankPage&enDisplay=view&enDispWhat=object&enVersion=0&enZone=Health>
 
before it starts

By Karin Kloosterman
November 04, 2008

A faint waft of men's cologne in a shopping mall. The smell of a 
neighbor's barbecue. A flash of a face on TV: small unexpected 
sensory cues can trigger extreme reactions in people who suffer from 
post-traumatic stress disorder (PTSD), about one quarter of all 
people who have lived through a traumatic event like rape, assault, 
war or terror attack.

New research by Israeli scientists from Ben Gurion University and Tel 
Aviv University, suggests that a large dose of a stress hormone may 
reduce the risk of PTSD, and its associated symptoms. The 
researchers, who report successful results in an animal model, are 
hoping this therapy could one day restore life to people who have 
experienced trauma.

Post-traumatic stress disorder is widely known to affect soldiers at 
war. But it can strike anyone who has suffered through a terrifying 
ordeal where life is at stake. According to the National Institute of 
Mental Health in the US, people with PTSD have persistent frightening 
thoughts and memories of their ordeal and feel emotionally numb, 
especially with people they were once close to.

"This breaks people's lives up," says Dr. Mike Matar, a psychiatrist 
affiliated with Ben Gurion University's Anxiety and Stress Research 
Unit, who participated in the study. People with PTSD "do less and 
less and less. Basically they are unable to put their lives back 
together," he tells ISRAEL21c.

Prevention method needed

Post-traumatic stress, Matar adds, is a major health cost in the US, 
and is a "hugely problematic disorder that destroys people lives." 
People, he explains, are supposed to respond to stress in proportion 
to the event. But in PTSD something goes wrong.

A high dose shot of corticosterone may prevent a high percentage of 
people, about one in four, from suffering from PTSD. The Israeli 
researchers reported their findings in the journal Biological Psychiatry.

Known as "the stress hormone," cortisol is secreted in high levels 
during a "fight or flight" reaction to stress, and it is this hormone 
that causes stress-related changes in the body.

Using mice, the researchers took a control group and a group of mice 
presented with a stress stimulus: litter soaked in cat urine. In 
about 25 percent of the cases, those presented with the cat urine 
litter exhibited symptoms of extreme stress, such as an increased 
startle response and behavioral freezing when exposed to reminders of 
the stress.

One shot could stop PTSD

The researchers found that those mice that were given high doses of a 
cortisol-related substance, corticosterone, immediately after 
exposure to a stressor could be spared from the negative consequences 
of the stress.

According to Dr. Hagit Cohen of the Anxiety and Stress Research Unit, 
Ben Gurion University, "Single high-dose corticosteroid treatment may 
thus be worthy of clinical investigation as a possible avenue for 
early pharmaco-therapeutic intervention in the acute phase, aimed at 
prevention of chronic stress-related disorders, such as PTSD."

The animal model developed by the Israeli researchers is also 
innovative, and is being adopted by a number of centers in the US, 
and internationally, to help investigators classify the animal's 
degree of response to negative stimuli.

<*}}}>< <http://www.holypostage.com/>Holy Postage <*}}}><
<*}}}><<http://www.halfthekingdom.org/>Half the Kingdom!<*}}}><

Prayer for Unborn Life:
O GOD OF LIFE AND LOVE, You have given us the gift to participate 
with You to bring new life into the world.  But, all too often, the 
mother's womb, which should be a nursery of life, becomes instead a 
place of it's destruction.

Help us to remove this evil and ensure respect for all life made in 
Your image and likeness, called to fulfill its promise on this earth,
and destined to find a home with you for all eternity.

We ask this through Jesus Christ, Our Lord, Our God, Our Savior, and Our ALL.
Amen.


<*}}}>< <http://www.holypostage.com/>Holy Postage <*}}}><
<*}}}><<http://www.halfthekingdom.org/>Half the Kingdom!<*}}}><

Prayer for Unborn Life:
O GOD OF LIFE AND LOVE, You have given us the gift to participate 
with You to bring new life into the world.  But, all too often, the 
mother's womb, which should be a nursery of life, becomes instead a 
place of it's destruction.

Help us to remove this evil and ensure respect for all life made in 
Your image and likeness, called to fulfill its promise on this earth,
and destined to find a home with you for all eternity.

We ask this through Jesus Christ, Our Lord, Our God, Our Savior, and Our ALL.
Amen.

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