Pesticide Exposure Boosts Parkinson's Risk by 60 Percent

<http://www.naturalnews.com/024891.html>http://www.naturalnews.com/024891.html

Sunday, November 23, 2008 by: David Gutierrez, staff writer


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(NaturalNews) A new study has provided one of the 
strongest links yet between pesticide use and Parkinson's disease.

A team of researchers from Duke University, Miami 
University and the Udall Parkinson's Disease 
Research Center of Excellence has found that 
people who were exposed to pesticides were 
substantially more likely to develop Parkinson's 
disease than closely related people who did not 
use so many pesticides, according to a study 
published in the journal BMC Neurology.

Parkinson's 
<http://www.naturalnews.com/disease.html>disease 
is a degenerative neurological condition 
resulting from the damage or death of the brain 
cells that regulate muscular movement. When cells 
become unable to produce the neurotransmitter 
dopamine, a wide variety of problems, such as 
slurred speech, stiffness, tremors, and problems 
with balance and movement, occur. Approximately 
one million people in the United States - one in 
300 - suffer from the disease. In the United 
Kingdom, approximately one in 500 people, or 120,000 people, are affected.

The researchers surveyed 319 people with 
<http://www.naturalnews.com/Parkinsons_disease.html>Parkinson's 
disease on their pesticide use, and compared that 
use to more than 200 healthy family members and 
other unaffected people. The purpose of comparing 
relatives was to control as much as possible for 
genetic and non-pesticide environmental factors 
by looking only at people with similar backgrounds.

"Previous studies have shown that individuals 
with 
<http://www.naturalnews.com/Parkinsons.html>Parkinson's 
disease are over twice as likely to report being 
exposed to 
<http://www.naturalnews.com/pesticides.html>pesticides 
as unaffected individuals," lead researcher Dana 
Hancock said, "but few studies have looked at 
this association in people from the same family 
or have assessed associations between specific 
classes of pesticides and Parkinson's disease."

People who had been exposed to pesticides had 1.6 
times the Parkinson's risk of people who had not 
been exposed, while those exposed for more than 
200 days in a year had more than two times the 
risk. The pesticides with the strongest 
connection to Parkinson's disease were 
insecticides and herbicides. Home and garden 
exposure were more strongly linked to increased risk than occupational use.

Broken down by sex, men who frequently used 
pesticides were 2.15 times more likely to develop 
the disease than men who did not use the 
chemicals, while women were 2.43 times more likely.

The researchers also compared rates of well-water 
drinking and living or working on a farm between 
people with and without the disease. They did not 
find a correlation between Parkinson's disease 
and any of these behaviors, which are commonly 
used as surrogate measures of pesticide exposure. 
Instead, the effect turned up only when they 
looked directly at chemical exposure.

Scientists have known for some time that the risk 
of Parkinson's disease is influenced by genetics, 
but the gene defects that have been linked to the 
disease account for only a small fraction of 
cases. Environmental factors have also been 
implicated, particularly in light of the fact 
that the disease was mostly unknown prior to the 
industrial revolution but has become a common ailment since then.

Prior studies have found links between pesticide 
exposure and Parkinson's risk, but they have not 
been thought conclusive. Kieran Breen, director 
of research at the Parkinson's Disease Society, 
cites a study of 10,000 Parkinson's patients that 
found only 1,000 had been exposed to pesticides 
over the long-term. The current study, Breen 
said, "strengthened the fact that pesticides play 
a key role" in risk of the disease.

"I think there is very strong evidence now 
linking [pesticide exposure and Parkinson's 
risk,]" Hancock said. The next step, Hancock 
said, is to discover the biological mechanisms by 
which pesticides increase the risk of the disease.

The findings of another study on the links 
between Parkinson's and pesticides, commissioned 
by the British Department of Environment, Food 
and Rural Affairs, are expected this summer.


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